Molecular approaches to limit herpesvirus recombination

该项目旨在通过对疱疹病毒基因组进行遗传操作来减少病毒重组，从而生产出更安全的减毒疱疹病毒疫苗，用于兽医。重组被认为是一系列减毒疱疹病毒疫苗的安全问题。该项目预计将产生与其他病毒重组能力受损的病毒。然后，这些病毒将作为候选疫苗进行测试，用于兽医。这为开发更安全的兽用疫苗提供了一种新的方法，这将使我们重要的畜牧业受益。

This project aims to generate safer attenuated herpesvirus vaccines for use in veterinary medicine by genetically manipulating the herpesvirus genome to reduce virus recombination. Recombination is recognised as a safety concern for a range of attenuated herpesvirus vaccines. This project is expected to generate viruses that have an impaired capacity to recombine with other viruses. These viruses will then be tested as candidate vaccines for use in veterinary medicine. This offers a new approach to developing safer veterinary vaccines that will benefit our important animal industries.