OSTEOPOROSIS IN MEXICAN AMERICANS AND NONHISPANIC WHITES

墨西哥裔美国人，一个庞大且不断增长的少数族裔人口， 髋部骨折的发生率约为非西班牙裔白人的一半。 这种较低风险的原因尚不清楚，但骨折较少。 其他种族群体，例如黑人的风险被归因于 更大的骨量。墨西哥裔美国人和美国人的骨量 骨量与危险因素的关系从未被研究过。 我们建议测定髋部和脊柱部位的骨量。 在临床上最重要的骨质疏松性骨折中， 400名墨西哥裔美国人和非西班牙裔美国人的人口样本 白人女性。对要检查的研究人群进行了跟踪 自1979年以来由圣安东尼奥心脏研究中心提供。几个风险因素 对于骨质疏松症，如肥胖、饮食、锻炼和药物使用 已经在这个人群中进行了前瞻性的研究。其他内容 骨质疏松症的危险因素将通过问卷和 骨量将通过双光子吸收法测量。这些 数据将被用来确定在骨量方面的任何差异 墨西哥裔美国人和非西班牙裔白人以及评估哪种风险 这些差异可能是由各种因素造成的。 这些数据也将被用来开发预测模型， 个体骨量的危险因素。此信息 可能会为临床医生和医疗保健提供有用的信息 规划者通过指示是否以及为谁增加了骨量测量 任何有关骨折风险的实质性信息超过所提供的 仅凭临床评估。

Mexican Americans, a large and growing minority population, have an incidence of hip fracture about 1/2 that of non-Hispanic whites. The reasons for this lower risk are unclear, but lower fracture risks in other ethnic groups, e.g., blacks, have been ascribed to greater bone mass. The bone mass of Mexican Americans and the relationship of bone mass to risk factors has never been examined. We propose to determine the bone mass of the hip and spine, sites of the most clinically important osteoporotic fractures, in a population based sample of 400 Mexican American and non-Hispanic white women. The study population to be examined has been followed since 1979 by the San Antonio Heart Study. Several risk factors for osteoporosis such as obesity, diet, exercise and medication use have been studied prospectively in this population. Additional risk factors for osteoporosis will be assessed by questionnaire and bone mass will be measured by dual photon absorptiometry. These data will be used to identify any differences in-bone mass between Mexican Americans and nonHispanic whites and to assess which risk factors might account for these differences. These data will also be used to develop predictive models relating risk factors to the bone mass of individuals. This information may yield useful information for clinicians and health care planners by indicating if and for whom bone mass measurements add any substantial information about fracture risk above that provided by clinical assessment alone.