HEAT EXCHANGE IN OBESITY

肥胖的Zucker大鼠被广泛用作肥胖的模型，但 与其脂肪状态相关的宏观能量学尚未得到 分割得令人满意。将对总能量进行测定 成年肥胖大鼠和瘦Zucker大鼠食物能量的平衡 摄入量、身体成分变化、总产热量和总热量 总产热量与体力活动分开造成的损失， 生热作用和食物摄取的热效应。直接和 间接量热法以及食物摄入量的评估和测量 身体成分的变化将被采用。同时使用DIRECT和 间接量热法将揭示材料的瞬时热响应。 瘦肉型和肥胖型动物对不同的环境温度。差异在于 注意体温损失，并与结肠温度有关。 改变。最初将使用成年动物，以避免 使年轻人成长的因素复杂化。我们希望测试一下 保持成年瘦小肥胖的Zucker大鼠的能量；这是我们的 能量平衡存在根本性差异的假说 这些动物，尤其是在寒冷或有压力的时候。结果为空 我们的调查结果表明， 能量平衡出现在成虫发育的成体前成熟阶段。 必须研究大鼠和正在成长和成熟的动物--改变 我们准备做出的强调。建议的研究结果 研究可能对确定与以下因素相关的因素具有重要意义 遗传性肥胖症及其治疗的适当建议 这样的状况。

The obese Zucker rat is widely used as a model for obesity, yet the macroscopical energetics related to its fatty state have not been satisfactorily partitioned. Determinations will be made of total energy balance of adult obese and lean Zucker rats for measurement of food energy intake, body compositional change, total heat production, and total heat loss with separation of total heat production into physical activity, thermogenesis, and the thermic effect of food ingestion. Direct and indirect calorimetry as well as food intake assessment and the measurement of change in body composition will be employed. Use of both direct and indirect calorimetry will reveal the transient thermal responses of the lean and obese animals to different ambient temperatures. Differences in body heat loss will be noted and associated with colonic temperature changes. Adult animals will be used initially in order to avoid the complicating factor of growth in the young. We wish to test the maintenance energetics of the adult lean and obese Zucker rat; it is our hypothesis that there is a fundamental difference in the energy balance of these animals, particularly when cold or otherwise stressed. A null result of our investigations would suggest that the fundamental difference in energy balance is to be found in the preadult maturation phase of growth of the rats and growing and maturing animals must be studied--a change in emphasis that we are prepared to make. The results of the proposed research may be significant in identifying factors associated with genetically linked obesity and in appropriate suggestions for treatment of such a condition.