PATHOGENESIS OF AIDS/HIV ASSOCIATED PSORIASIS

严重的爆发性银屑病和/或赖特氏综合征可能是早期 HIV感染的皮肤表现，预后不良 艾滋病的发展--获得性免疫缺陷综合征。这个 银屑病与HIV感染之间的关联表明 免疫学基础和可能的传染性基础 银屑病的发病机制。齐多夫定治疗迅速痊愈 银屑病为认识银屑病提供了重要的临床模型 银屑病及其与艾滋病的关系。类似的活组织检查 和HIV+和HIV-银屑病患者的外周血淋巴细胞 齐多夫定治疗后将对免疫细胞进行研究 人群、DR抗原和细胞因子的表达与HIV感染 使用双重免疫过氧化物酶和免疫荧光抗体， 以及用于原位的核探针和35S-UTP标记的核探针 杂交。艾滋病/银屑病中的人类白细胞抗原相关性将是 利用Southern blotting检测DR、DQ和C基因座的研究 探测器。艾滋病相关性银屑病与齐多夫定的相关性分析 分子水平的诱导缓解应该会导致更好的 对银屑病发病机制及其相关性的认识 感染艾滋病毒，以及更好、更安全的牛皮癣治疗 将军。

Severe explosive psoriasis and/or Reiter's syndrome may be an early cutaneous manifestation of HIV infection with a poor prognosis for development of AIDS - the acquired immunodeficiency syndrome. The association between psoriasis and HIV infection suggests an immunologic basis and possibly an infectious basis for the pathogenesis of psoriasis. Zidovudine therapy rapidly clears psoriasis and offers an important clinical model for understanding psoriasis and its observed association with AIDS. Akin biopsies and peripheral lymphocytes from HIV+ and HIV- psoriatics before and after zidovudine therapy will be studied for immunologic cell populations, DR antigen, and cytokine expression, and HIV infection using double immunoperoxidase and immunofluorescence antibodies, and riboprobes and 35S-UTP labeled riboprobe for in situ hybridization. HLA antigen associations in AIDS/psoriasis will be explored using Southern blotting to DR, DQ, and C locus cDNA probes. Analysis of AIDS associated psoriasis and the zidovudine induced remission at the molecular level should lead to a better understanding of the pathogenesis of psoriasis, its association with HIV infection, and better, safer therapy for psoriasis in general.