PULMONARY SURFACTANT SYSTEM AND RADIATION PNEUMONITIS

肺炎和肺纤维化的频繁发生， 放射疗法和/或化学疗法在联合模式癌症治疗中的应用 这促使人们寻找一种预测指数。 的发病率和死亡率 在弥漫性肺炎或纤维化发作后， 在临床前阶段对该实体的识别可以允许 采取干预措施，以避免其发生。 为此，我们进行了研究， 作为理解辐射的起点 肺炎。 II型肺细胞已被证明是早期靶点 并在暴露后不久将表面活性剂释放到肺泡中。 通过使用灌洗技术，肺泡表面活性物质已被证明是 肺照射后升高。 肺结石发生4例 月后，在LAF，小鼠，表明与表面活性剂的强相关性 在7天和28天释放。 因此，进一步的实验是 建议细化II型肺细胞的急性生化改变 作为后续影响的预测指标。 当这些变化在 在小鼠的体外和体内研究中，它们将作为 更大的动物诊断模型（兔和狗）， 辐射对人体的影响之间的因果关系 II型肺细胞，其他肺细胞和肺炎和纤维化， 将在各种相关的生化，组织学和 超微结构技术 辐射响应的修正研究 通过不同的放射分割方案和化疗， 还将研究防辐射剂。 表面活性剂，其 II型肺细胞中其他变化的前体有可能 这是第一个早期的生化标记，为后期辐射效应。

The frequent occurrence of pneumonitis and pulmonary fibrosis secondary to radiation therapy and/or chemotherapy in combined modality cancer treatment has led to search for a predictive index. The morbidity and mortality after the onset of a diffuse pneumonitis or fibrosis is high and recognition of this entity in the pre-clinical phase may allow for interventions to avoid its onset. Toward this end, we have pursued studies on Type II pneumocyte as a beginning point to understand radiation pneumonitis. The Type II pneumocyte has been shown to be an early target of radiation and releases surfactant into alveoli shortly after exposure. By use of lavaging techniques, alveolar surfactant has been shown to be elevated after pulmonary irradiation. Pulmonary lethalith occurred four months later in LAF, mice, indicating a strong correlation with surfactant release at 7 and 28 days. For this reason, further experiments are proposed to refine the acute biochemical alterations of Type II pneumocytes as a predictor for later effects. When these changes are identified in in vitro and in vivo studies on mice, they will be studied as markers in larger animal diagnostic models (rabbits and dogs) prior to their introduction in man. The causal relationship between radiation effects on Type II pneumocytes, other pulmonary cells and pneumonitis and fibrosis, will be evaluated in a variety of correlated biochemical, histological and ultrastructural techniques. Studies on modification of radiation response by different radiation fractionation schema and to chemotherapeutic and radioprotective agents will also be under study. Surfactant, its precursors on other changes in Type II pneumocytes has the potential for being the first early biochemical marker for late radiation effects.