LENT V CONFERENCE

描述（由申请人提供）：有令人信服的理由组织放射生物生理学和生物病理学的RTOG转化研究研讨会，结合新的分子生物学和遗传学概念，寻找可量化的替代生物标志物，用于对正常组织中的不良反应进行分级。 此外，已经并将设计创新的治疗干预措施，以减轻基于分子机制的不良反应。 其他目标是制定一个标准的统计模型，用于报告不良反应和统一的方法来达到一个总结或全球毒性评分。 替代生物标志物的目标可用于辐射生物恐怖事件，以确定已暴露于辐射的个人。 参与的教师将被邀请临床科学家和研究人员与正常组织（LENT）的迟发效应的长期兴趣。 将向所有主要的国家肿瘤学合作组和EORTC发出公开邀请，以促进验证方案，并激发对建立有意义的治疗比例的兴趣。 会议将在罗切斯特大学癌症中心、纪念美术馆和AAB基础科学礼堂举行。 将在一系列面向器官的小型重点讲习班中讨论一些重要议题。 会议定于2004年5月19日、20日、21日和22日举行。

DESCRIPTION (provided by applicant): There are compelling reasons to organize an RTOG translational research workshop in radiation biophysiology and biopathology incorporating new molecular biologic and genetic concepts in search of quantifiable surrogate biomarkers for grading adverse effects in normal tissues. In addition, innovative therapeutic interventions have been and will be designed to ameliorate adverse effects based on molecular mechanisms. Additional goals are to develop a standard statistical model for reporting adverse effects and a unified approach to arriving at a summary or global toxicity score. The goal of surrogate biomarkers can be utilized in the event of radiation bioterror to determine individuals that have been exposed to radiation. The participating faculty will be invited clinical scientists and researchers with a long-standing interest in Late Effects of Normal Tissues (LENT). An open invitation will be made to all major National Oncology Cooperative Groups and the EORTC to foster validation protocols and stimulate interest in establishing meaningful therapeutic ratios. The meeting will be held at the University of Rochester Cancer Center, The Memorial Art Gallery, and the AAB Basic Science Auditoriums. A number of vital topics will be addressed in a series of small focused workshops which will be organ oriented. The dates selected for the Conference are May 19, 20, 21,22 2004.