STEROID ANAEROBIC AROMATIZATION & BOWEL CANCER

有证据表明，从人类粪便中分离出的厌氧微生物 能够有效代谢胆汁酸和其他类固醇 酸。结果表明，粪便中的厌氧菌能(A)使啤酒芳香化。 类固醇核产生雌激素和萘类似物，(B)裂解 C24-酸到C22-酸和C19-雄激素的侧链，和(C) 在类固醇核中引入双键。也就是说，厌氧 粪便(厌氧菌)对类固醇的芳构化应不同于 已知的哺乳动物雌激素生物合成的有氧机制。 有人推测，脱氢和芳构化反应 类固醇的过程可能是前致癌物形成的一种衡量标准， 共致癌物或系统中的致癌物。对这一问题的理解 芳构化过程的机理可能导致芳构化反应的发展 抗癌药物。 我们的目标是研究厌氧生物合成的代谢途径。 雌激素的作用。

Evidence was obtained that anaerobic organisms isolated from human feces are capable of effectively metabolizing bile acids and other steroidal acids. It was shown that the fecal anaerobes can (a) aromatize the steroidal nucleus to yield estrogens and naphthalenic analogs, (b) cleave the side chain of C24-acids to C22-acids and C19-androgens, and (c) introduce double bonds in the steroidal nuclei. By implication, anaerobic aromatization of steroids by the fecal (anaerobes) should differ from the known aerobic mechanism of biosynthesis of estrogen in mammals. It was inferred by others that the dehydrogenation and aromatization processes of steroids may be a measure of the formation of pro-carcinogens, co-carcinogens or carcinogens in the system. The understanding of the mechanisms of the aromatization process could lead to the development of anti-cancer agents. Our objective is to study the metabolic pathway of anaerobic biosynthesis of estrogens.