DETECTION OF BLADDER AND KIDNEY TUMORS BY CELL MIGRATION

我们最近发现移行细胞患者的尿液 膀胱癌和肾癌明显刺激 毛细血管和内皮Balb 3T3细胞比尿液具有更大的迁移能力 来自正常人、良性疾病患者或患者 他们的肿瘤都被切除了。我们的目标是进一步调查这一点 并确定尿液中的这一特性是否可以用来检测 新发和复发的膀胱和肾脏肿瘤。我们计划确定 这些因素扰乱了细胞迁移的水平，以及可以采取什么措施 使化验标准化。我们还将把这项检测与尿液进行比较。 细胞学检查以确定作为高危人群筛查试验的潜在有用性 有风险的病人。我们计划进一步表征并开始提纯 尿液中的物质导致了这种观察，因为从长远来看 这项工作的目的是开发一种新的非侵入性膀胱检测方法 以及可以广泛使用的肾脏肿瘤。这样的一次考验 将导致对这些疾病患者的更好管理。

We have recently found that urine from patients with transitional cell carcinoma of the bladder and renal cell carcinoma stimulate significantly greater migration of capillary and endothelial Balb 3T3 cells than urine from either normal individuals, patients with benign diseases or patients who have had their tumors removed. Our aim is to further investigate this phenomenon and determine if this property in urine can be used to detect new and recurrent bladder and kidney tumors. We plan to determine what factors upset the level of cell migration and what can be done to standardize the assay. We will also compare this assay with urinary cytology to determine the potential usefulness as a screening test in high risk patients. We plan to further characterize and begin to purify the substance in urine responsible for this observation, because the long term objective of this work is to develop a new, noninvasive test for bladder and kidney tumors that can be used on a widespread basis. Such a test would result in better management of patients with these diseases.