THE CHEMISTRY OF TECHNETIUM RELATED TO NUCLEAR MEDICINE

这项研究旨在更好地了解 的锝，并利用这一知识的合理设计新的 掺入放射性核素99mTc的放射性药物。 从已经表征的氧化态明确的化合物开始 复合物的制备、分离和研究将采用已经被广泛采用的方法。 成功地应用于其他过渡金属的配位化学。 合成程序的目的是给出氧化态的分布， 立体化学，键合的性质和相对配体亲和力， 锝化合物 随着元素行为的系统化出现， 信息将应用于材料的设计和合成， 显示出作为放射诊断剂潜力。 然后将在 合适的动物模型。

This investigation is designed to achieve a greater understanding the chemistry of technetium, and to use this knowledge in the rational design of new radiopharmaceuticals incorporating the radionuclide 99mTc. Beginning with already characterized compounds in well-defined oxidation states complexes will be prepared, isolated and studied using methods which have been successfully applied to the coordination chemistry of other transition metals. The aim of the synthetic program is to give a profile of the oxidation state, stereochemistry, nature of the bonding and the relative ligand affinities of technetium compounds. As the systematics of the element's behavior emerge, this information will be applied to the designing and synthesizing of materials which show potential as radiodiagnostic agents. These will then be evaluated in appropriate animal models.