IN UTERO DES EXPOSURE: CANCER AND MEDICAL ILLNESSES

该项目的目的是增加约22，500人年， 在5，464名患者中发现癌症和其他重大医疗疾病 以前参加过荒漠化和干旱十年项目的妇女。 这 持续的监察将使我们能够达到五个具体目标： 确定暴露在暴露的鳞状细胞瘤的过度程度， 未暴露的妇女，并确定增加的风险是否继续超过 未来五年，以确定腺癌的风险是否增加 在未来五年内，确定严重医疗事故的发生率， 暴露于DES的妇女中的疾病，并将这些比率与 对照组和已公布的年龄特异性发病率 疾病，以确定腹部和妇科手术的频率 暴露于DES的女性中，并将这些比率与未暴露的女性进行比较， 控制和国家卫生中心提供的比率 统计数据，并与荒漠化十年项目受影响群体保持联系 以最小的代价。 这些目标将通过以下方法收集信息来实现： 邮寄问卷。 每个参与者每年都会被询问一次 关于内科疾病的诊断或外科手术的执行 程序. 荒漠化十年队列的以往经验表明， 以前参加该项目的妇女中有90%以上可以 预期将遵守提供信息的要求。 样本量 注意事项在项目中详细解释，并指出， 将有可能检测到，以0.9的功效， 许多常见的内科疾病和外科手术的发病率 p= 0.05水平。

The purpose of this project is to add approximately 22,500 person years for the detection of cancer and other major medical illnesses among the 5,464 women who have previously been enrolled in the DESAD Project. This continued surveillance will enable us to accomplish five specific aims: to determine the magnitude of the excess of squamous neoplasia in exposed over unexposed women and to determine if the increased risk continues over the next five years, to determine if the risk of adenocarcinoma increases during the next five years, to determine the rates of serious medical illnesses in the DES exposed women and to compare these rates with the control groups and published age specific incidence rates for the same diseases, to determine the frequency of abdominal and gynecologic surgery among DES exposed women and to compare these rates with the unexposed controls and the rates available from the National Center for Health Statistics, and to maintain contact with the DESAD Project exposed cohort at minimal expense. These aims will be accomplished by soliciting information by the method of mailed questionnaire. Each participant will be questioned annually concerning the diagnosis of medical diseases or the performance of surgical procedures. Previous experience of the DESAD cohort has indicated that in excess of 90 percent of the women previously enrolled in the project can be expected to comply with the requests for information. The sample size considerations are explained in detail in the project and indicate that it will be possible to detect, with a power of .9, a two-fold difference in the rates of many common medical diseases and surgical procedures at the p=.05 level.