NMR RELAXATION TIMES OF ALKALI METAL IONS

23 Na成像可能比质子成像具有某些优势， 诊断目的。 为了使用这种技术，重要的是 了解决定23 Na弛豫时间的各种因素。 它 本文拟对~（23）Na弛豫进行系统的研究 在生物组织中： a.为了找到细胞和体液中负责23 Na的成分， 放松. B.通过23 Na NMR表征正常和病理组织 弛豫和信号强度。 待研究的系统是血液及其成分、CSF、培养的 细胞，整个器官，如灌注的大鼠心脏和腿和大脑的活 大鼠和最后各种肿瘤组织，植入小鼠和样品中， 在外科手术中切除的人体肿瘤。 为了获得这些数据，必须开发一些技术， 非均相体系中多组分弛豫时间的测量 以及在使用表面线圈的测量中。 因此，我们希望能够了解钠弛豫， 生物组织，并能够区分各种类型的 组织损伤如水肿、局部缺血以及各种肿瘤， 他们的发展状态。

23Na imaging may have some advantages over proton imaging for certain diagnostic purposes. In order to use this technique it is important to understand the various factors determining the 23Na relaxation times. It is proposed here to perform a systematic investigation of 23Na relaxation in biological tissues: a. To find the components of cells and body fluids responsible for the 23Na relaxation. b. To characterize normal and pathological tissues by their 23Na NMR relaxation and signal intensities. The systems to be investigated are blood and its components, CSF, cultured cells, whole organs such perfused rat hearts and legs and brain of live rats and finally various tumorous tissues, implanted in mice and samples or human tumors removed in surgical operations. In order to obtain this data some techniques will have to be developed for the measurement of multicomponent relaxation times in heterogeneous systems and in measurements using surface coils. As a result we hope to be able to understand sodium relaxation in biological tissues and to be able to differentiate between various kinds of tissue damages such as edema, ischemia, as well as various tumors and the state of their development.