DEVELOP NEW CLASS OF CHEMICAL RADIOSENSITIZATION

这项研究的长期目标是开发一种新的 化学放射增敏剂。 为了达到我们的整体目标， 计划将是： a.从不含以下物质的类别中合成潜在的放射增敏剂： 硝基，特别是异吲哚醌; B.确定这些化合物的物理化学性质; C.确定这些醌的辐射化学特性 衍生物; D.使用体内方法测定这些化合物的毒性和细胞毒性 和体外系统; e.测定异吲哚的放射增敏潜力 使用EHS肉瘤和KHT肉瘤的体内系统中的醌 移植到小鼠体内; F.研究这些化合物的作用机制， 放射和化学治疗的联合方式 癌组织 希望这些调查将为 开发一类新的化学放射增敏剂， 一些目前测试的药物遇到的不希望的副作用 致敏剂。

The long range goal of the proposed research is to develop a new class of chemical radiosensitizers. In order to achieve our overall objective, our plan will be to: a. Synthesize potential radiosensitizers from a class that does not contain a nitro group, specifically isoindole quinones; b. determine physicochemical properties of these compounds; c. determine the radiation chemical characteristics of these quinone derivatives; d. determine the toxicity and cytotoxicity of these compounds using in vivo and in vitro systems; e. determine the radiosensitization potentialities of the isoindole quinones in an in vivo system using EHS sarcoma and KHT sarcoma transplanted in mice; f. investigate the mechanism of action of these compounds using different combined modalities in the radiation and chemical therapeutic treatment of cancerous tissues. It is hoped that these investigations will provide a basis for the development of a new class of chemical radiosensitizers, which may lack the undesired side effects encountered with some of the currently tested sensitizers.