TUMOR PHOTOTHERAPY--NEW PHOTODYNAMIC SENSITIZERS

这是一个新的应用程序，涉及到开发和 新一代光敏剂的优化 肿瘤和其他健康的光动力疗法(PDT) 条件。选择进行研究的分子是化学上的 萘酞菁(NC)家族。NC基于一个 四维大旋回。初步光生理研究 已经显示出这一类的一位代表有光 所需的吸收和光化学特性 为了改善光敏剂的性能 (血卟啉衍生物)目前正在接受化学治疗 审判。该程序涉及一个合成面，其中NC的 不同的结构、光吸收和溶解性 将被合成和表征(M.E.肯尼博士将 在此进行协作)。有一个方面需要使用时间- 用解析动力学方法量化光物理性质 在各种环境中的指定系统。第三 方面涉及细胞和动物的光生物学研究 肿瘤水平(最后一项与G.Jori博士合作)。这个 这项研究将在三个实验室进行 设备齐全，设施齐全。

This is a new application that concerns the development and optimization of a new generation of photosensitizers for photodynamic therapy (PDT) of tumors and other health conditions. The molecules selected for study are, chemically, of the naphthalocyanine (NC) family. NC's are based on a tetrapyrroloid macrocycle. Preliminary photophysicial studies have shown one representative of this class as having light absorption and photochemical characteristics that are required for improving upon the performance of the photosensitizer (hematoporphyrin derivative) currently undergoing chemical trials. The program involves a synthetic facet in which NC's of different structure, optical absorption and solubility properties will be synthesized and characterized (Dr. M. E. Kenny will collaborate here). There is a facet that requires the use of time- resolved kinetic methods to quantify the photophysical properties of the designated systems in a variety of environments. The third facet involveds photobiological studies at the cellular and animal tumor level (these last in collaboration with Dr. G. Jori). The three laboratories where this research will proceed are all excellently equipped with the requisite facilities.