STRESS-INDUCED ANALGESIA IN MAN

这项研究旨在研究压力的时间进程- 诱导镇痛（SIA）和情绪和血浆中的升高 剧烈体育运动对人体内分泌的影响; 确定内源性阿片样物质的相对贡献， 非阿片类因素对这些现象;寻找显着的 关系，如果有的话，在SIA，情绪升高和各种 血浆内分泌水平;并测试SIA是一种 非特异性现象-即，压力不仅会加剧疼痛 阈值但也包括其它感觉阈值-例如，听觉 阈值。 这项研究将在96年进行， 科目 将留置导管插入 每例受试者的肘前静脉用于采集血样， 注射纳洛酮或安慰剂。 热辨别力测试， 缺血性疼痛敏感性、听觉辨别力和情绪 调查问卷将在之前，期间和之后进行 在纳洛酮或生理盐水条件下， 条件 在注射前、注射中和注射后采集的血样 将分析跑步机应激的血浆ACTH，β- 内啡肽- IR（β-内啡肽样免疫反应性），催乳素， 肾上腺素和去甲肾上腺素。 测试结果将根据 适当的数据分析;此外，热疼痛测试数据 将受到感官决策理论的分析。 在运动中受伤的痛苦被减轻的运动鞋 事件、事故或战斗的压力是常见的 知识，有时是个人经验，通常是主题 轶事的故事 尽管这种情况经常发生， 令人惊讶的是，这一现象几乎没有得到系统的研究， 人类，虽然SIA是一个积极的研究领域， 实验室动物 拟议的调查是一项实验性的 试图在人类身上检验这种现象，测试它的特异性 并确定其与内源性阿片疼痛的关系 监管机制。 在研究情绪提升效应时， 这项研究还提供了一个机会， 内源性阿片类物质在情绪调节中的可能作用。

This study is designed to examine the time course of stress- induced analgesia (SIA) and the elevations in mood and plasma endocrine levels produced in man by strenuous physical exercise; to determine the relative contributions of endogenous opioid and non-opioid factors to these phenomena; to look for significant relationships, if any, among SIA, mood elevation and various plasma endocrine levels; and to test the possibility that SIA is a non-specific phenomenon - i.e., that stress elevates not only pain thresholds but other sensory thresholds as well - e.g., auditory thresholds. The study will be carries out with the aid of a treadmill in 96 subjects. An indwelling catheter will be inserted into an antecubital vein of each subject for drawing blood samples and injecting naloxone or placebo. Tests for thermal discriminability, ischemic pain sensitivity, auditory discriminability and a mood questionnaire will be administered before, during and after various intensities of theadmill stress - under naloxone or saline conditions. Blood samples taken before, during and after the treadmill stress will be analyzed for plasma ACTH, beta- endorphin - ir (beta-endorphin like immunoreactivity), prolactin, epinephrine and norepinephrine. Test results will be subjected to appropriate data analysis; additionally the thermal pain test data will be subject to sensory decision theory analysis. Instances in which the pain of injury is dulled during athletic events, accidents, or the stress of battle are matters of common knowledge, sometimes personal experience, and often the subjects of anecdotal accounts. Despite the common occurence of this phenomenon it has received surprisingly little systematic study in humans, although SIA is an area of active investigation in laboratory animals. The proposed investigation is an experimental attempt to examine the phenomenon in man, test its specificity and determine its relationship to endogenous opioid pain regulatory mechanisms. In examining the mood-elevating effects of exercise the study also provides an opportunity to investigate a possible role of endogenous opioids in mood regulation.