COMPUTER ALGORITHMS FOR ACCURATE PHOTON DOSE CALCULATION

拟议研究的目的是开发计算机算法，用于 肿瘤外照射治疗中吸收剂量的准确计算 光子束。这不仅需要发展精确度 光子剂量计算的解析方法及其实现 作为以提供计算速度的方式的计算机算法 对于常规的临床实践来说足够高。我们的目标是在 这些计算机算法的整个精确度为5%，或者最好是3% 治疗体积。 在拟议的研究中，光子束的五个剂量沉积过程 已经被确认了。这些过程中的每一个都将被建模 从理论上讲，然后将开发实用的计算机算法 每一个都是。(在这个初始项目期之后的研究中，计算机 算法将得到扩展，以便提供准确的剂量 实际临床治疗机的计算。) 在拟议的三年研究中，两位理论物理学家 (总时间由一名全职人员负责) 为了从基本规律出发发展五个剂量沉积模型 物理，然后在数学上简化它们以实现为 由全职计算机程序员编写的计算机算法。此外， 计算机程序员将继续执行EGS4蒙特卡罗 检查理论模型和它们的准确性的计算 伴随而来的算法。

The purpose of the proposed research is to develop computer algorithms for the accurate calculation of absorbed dose in cancer treatment with external photon beams. This will entail the development not only of accurate analytic methods of photon dose calculation, but also their implementation as computer algorithms in ways which provide calculation speed which is sufficiently high for routine clinical practice. The goal is to achieve in these computer algorithms an accuracy of 5%, or preferably 3%, throughout the treatment volume. For the proposed research, five dose-deposition processes for photon beams have been identified. Each of these processes will be modeled theoretically, and then practical computer algorithms will be developed for each one. (In research subsequent to this initial project period, computer algorithms are to be expanded so that they provide accurate dose calculation for realistic clinical treatment machines.) During the three years of proposed research, two theoretical physicists (with total time commitment of one full-time person) will be responsible for developing the five dose-deposition models from the basic laws of physics, and then mathematically simplifying them for implementation as computer algorithms by a full-time computer programmer. In addition, the computer programmer will continually carry out EGS4 Monte Carlo calculations to check the accuracy of the theoretical models and their attendant algorithms.