ELECTRON DOSE CALCULATION USING THE BIPARTITION

使用二分法计算电子剂量

• 批准号: 2669173
• 负责人: DAVID JETTE
• 金额: $ 2万
• 依托单位: LAWRENCE H. LANZL INST OF MED PHYSICS
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2669173
• 关键词: electron transport; mathematical model; model design /development; neoplasm /cancer radiation therapy; radiation dosage; statistics /biometry

Electron beams are now in widespread use in the radiation treatment of cancer because their rapid dose falloff minimizes irradiation of critical healthy tissues beyond the treatment volume. Unfortunately, for treatment planning purposes it is not yet possible to routinely calculate the absorbed dose distribution accurately, particularly in the presence of localized tissue inhomogeneities such as air cavities, bone, and lung. The overall goal of the proposed research is to develop electron dose- calculation algorithms which are sufficiently accurate for the most complicated situations expected to be encountered clinically, yet practical in the sense of being able to be implemented in a computerized treatment planning system (short enough calculation time). The goal of the project is to achieve in these computer algorithms an accuracy of 5%, or preferably 3%, throughout the treatment volume. A Bipartition Model for electron transport has already been developed, and this model will be extended through incorporation of recent multiple- scattering theories describing the forward-directed beam electrons. This will be accomplished through use of the basic laws of physics in conjunction with mathematical simplification of the resulting formulas, to obtain short calculation times while maintaining accuracy. The accuracy of the combined model as it develops will continually be checked through EGS4 Monte Carlo calculations and, later into the project, with experimental dose distributions using a medical electron linear accelerator.

电子束现在广泛应用于放射治疗