PHARMACOLOGICAL MODULATION OF COCAINE EFFECTS

该项目将研究人类可卡因使用者的相互作用， 目前使用或拟议用于毒品贩运的毒品 可卡因滥用的治疗。 此外，该项目还将审查 可卡因对美沙酮维持治疗患者的影响， 可卡因滥用的高风险人群。 该项目旨在 识别潜在的益处（例如，阻断有效性 可卡因效应）和潜在有害（例如，变化 心血管功能或可卡因引起的欣快感增加） 可卡因自我给药时产生的影响 药物治疗。 在一个居住的人类 实验室的生理，主观， 单独和联合可卡因激发的行为效应 将在受控条件下进行深入研究 双盲条件。 在第一项研究中， 将单独在美沙酮依赖的可卡因滥用者中进行比较 以及非阿片类药物滥用者。 研究以审查 两种抗抑郁药重复给药的效果， 地昔帕明和曲唑酮对可卡因激发的反应将 然后在滥用美沙酮维持治疗的患者中进行， 可卡因 第二组研究将考察 可卡因与拟用于可卡因滥用的药物之间的关系 治疗（氟哌啶醇、溴隐亭、金刚烷胺和1-多巴） 非阿片类药物依赖的可卡因滥用者。 这些实验将 提供关于安全性和有效性的多方面数据， 在高风险人群中的各种药物 可卡因的自我管理，并可能提供有关 这是决定可卡因滥用者治疗的基础。

This project will examine in human cocaine users the interactions of cocaine with drugs currently used or proposed for use in the treatment of cocaine abuse. In addition, the project will examine the effects of cocaine in methadone maintenance patients, a population at high risk for cocaine abuse. The project aims to identify potentially beneficial (e.g., efficacy in blockade of cocaine effects) and potentially harmful (e.g., changes in cardiovascular function or increases in cocaine-induced euphoria) effects produced when cocaine is self-administered during treatment with pharmacological agents. In a residential human experimental laboratory the physiological, subjective, and behavioral effects of cocaine challenge alone and in combination with a test drug will be intensively studied under controlled double-blind conditions. In the first study the effects of cocaine alone will be compared in methadone-dependent cocaine abusers and in non-opioid using cocaine abusers. Studies to examine the effect of repeated administration of two antidepressants, desipramine and trazodone, on response to cocaine challenge will then be conducted in methadone maintenance patients who abuse cocaine. A second group of studies will examine the interaction between cocaine and drugs proposed for use in cocaine abuse treatment (haloperidol, bromocriptine, amantadine, and 1-dopa) in non-opioid dependent cocaine abusers. These experiments will provide multifaceted data concerning the safety and efficacy of various pharmacological agents in a population at high risk for self-administration of cocaine and may provide information on which to base decisions about the treatment of cocaine abusers.