STRESS-INDUCED ANALGESIA IN MAN

这项研究旨在研究压力的时间进程-- 诱导镇痛(SIA)及其对情绪和血浆的影响 通过剧烈的体育锻炼产生的人体内分泌水平； 确定内源性阿片类药物的相对贡献和 非阿片类因素对这些现象的影响；寻找有意义的 SIA、情绪提升和各种因素之间的关系 血浆内分泌水平；并测试SIA是一种 非特定现象--即，压力不仅会增加疼痛 阈值，以及其他感觉阈值--例如，听觉 阈值。 这项研究将在96年的跑步机的帮助下进行 研究对象。留置导尿管将被插入 每个受试者的肘前静脉采集血样和 注射纳洛酮或安慰剂。热辨别性测试， 缺血性疼痛敏感度、听觉辨别力和情绪 问卷将在之前、期间和之后进行 不同强度的草莓应激--在纳洛酮或生理盐水下 条件。在手术前、手术中和手术后采集血液样本 将对跑步机负荷进行分析，以检测血浆ACTH、β- 内啡肽-IR(β-内啡肽样免疫反应)，催乳素， 肾上腺素和去甲肾上腺素。测试结果将以 适当的数据分析；此外，热痛测试数据 将接受感官决策理论的分析。 在运动中使受伤的疼痛变得迟钝的例子 事件、事故或战争的压力都是常见的事情 知识，有时是个人经验，经常是主题 轶事故事。尽管这种情况屡见不鲜 令人惊讶的是，对它的系统研究很少 人类，尽管SIA是一个积极调查的领域 实验动物。拟议的调查是一项试验性的研究 试图检查人类的这一现象，测试其特异性 并确定其与内源性阿片类疼痛的关系 监管机制。在研究提升情绪的效果时 这项研究还提供了一个机会来调查 内源性阿片类药物在情绪调节中的可能作用。

This study is designed to examine the time course of stress- induced analgesia (SIA) and the elevations in mood and plasma endocrine levels produced in man by strenuous physical exercise; to determine the relative contributions of endogenous opioid and non-opioid factors to these phenomena; to look for significant relationships, if any, among SIA, mood elevation and various plasma endocrine levels; and to test the possibility that SIA is a non-specific phenomenon - i.e., that stress elevates not only pain thresholds but other sensory thresholds as well - e.g., auditory thresholds. The study will be carries out with the aid of a treadmill in 96 subjects. An indwelling catheter will be inserted into an antecubital vein of each subject for drawing blood samples and injecting naloxone or placebo. Tests for thermal discriminability, ischemic pain sensitivity, auditory discriminability and a mood questionnaire will be administered before, during and after various intensities of theadmill stress - under naloxone or saline conditions. Blood samples taken before, during and after the treadmill stress will be analyzed for plasma ACTH, beta- endorphin - ir (beta-endorphin like immunoreactivity), prolactin, epinephrine and norepinephrine. Test results will be subjected to appropriate data analysis; additionally the thermal pain test data will be subject to sensory decision theory analysis. Instances in which the pain of injury is dulled during athletic events, accidents, or the stress of battle are matters of common knowledge, sometimes personal experience, and often the subjects of anecdotal accounts. Despite the common occurence of this phenomenon it has received surprisingly little systematic study in humans, although SIA is an area of active investigation in laboratory animals. The proposed investigation is an experimental attempt to examine the phenomenon in man, test its specificity and determine its relationship to endogenous opioid pain regulatory mechanisms. In examining the mood-elevating effects of exercise the study also provides an opportunity to investigate a possible role of endogenous opioids in mood regulation.