MARIJUANA: EFFECTS OF REPEATED SMOKING

这项研究将检查吸食大麻对行为的影响， 中度大麻吸食者。 各种行为和生理 将测量变量，包括心率，主观情绪状态， 心理表现和认知功能。 的新颖方面 拟议的研究将使用呼出的空气一氧化碳水平作为一个 大麻烟雾吸入的定量指标。 Delta9的血浆水平 THC也将被确定并与CO水平和其他药物相关。 方面的影响. 两项拟议的研究涉及大麻自我管理。 第一 将研究香烟THC浓度对吸食大麻的影响 行为通过确定大麻吸烟者是否调整他们的摄入量， THC吸烟时含有不同水平的THC。 第二 这项研究将研究吸烟的辨别刺激特性。 通过训练吸烟者区分安慰剂和活性大麻， 大麻 这一程序可用于筛选新的化合物 有大麻样的主观效果，可能还有依赖性。 第三项研究将评估累积给药程序， 快速、可复制的剂量效应函数。 这样的 程序将允许研究人员获得剂量效应函数， 这将对今后的研究非常有用， 对吸食大麻的敏感性的变化（例如，研究宽容和 交叉耐受、致敏和药物相互作用）。 最后的研究将确定吸食大麻是否会产生残留 “宿醉”的影响后的第二天吸烟。 虽然有一些传闻 和实验证据表明， 吸食大麻，没有明确设计的研究， 解决这个问题。 这项研究将有助于描述任何 观察到的宿醉效应和给药条件下，他们 开发. 这种后遗症可能具有重要的和尚未认识到的 公共卫生影响。

This research will examine the behavioral effects of smoked marijuana in moderate marijuana smokers. A variety of behavioral and physiologic variables will be measured, including heart rate, subjective mood states, psychomotor performance, and cognitive function. A novel aspect of the proposed research will be use of expired air carbon monoxide level as a quantitative index of marijuana smoke inhalation. Plasma levels of Delta9 THC will also be determined and correlated with CO levels and other drug effects. Two proposed studies relate to marijuana self-administration. The first will examine the effect of cigarette THC concentration on marijuana smoking behavior by determining whether marijuana smokers adjust their intake of THC when smoking cigarettes containing different levels of THC. The second study will examine the discriminative stimulus properties of smoked marijuana by training smokers to discriminate placebo from active marijuana. This procedure could prove useful for screening new compounds for marijuana-like subjective effects, and possibly dependence potential. A third study will evaluate a cumulative dosing procedure for obtaining rapid, replicable dose-effect functions for smoked marijuana. Such a procedure would allow investigators to obtain dose-effect functions in a single session, which would be very useful for future studies examining changes in sensitivity to smoked marijuana (e.g., studies of tolerance and cross-tolerance, sensitization, and drug interactions). The final study will determine whether marijuana smoking produces residual "hangover" effects the day after smoking. Although there is some anecdotal and experimental evidence for the existence of hangover effects after marijuana smoking, there have been no studies explicitly designed to address this issue. This study will help to characterize the nature of any observed hangover effects and the dosing conditions under which they develop. Such hangover effects may have important and as yet unrecognized public health implications.