PERIODONTAL TISSUE CHANGES DURING PREGNANCY-LACTATION

牙周组织在青春期、怀孕期和 在女性更年期后。 例如，在怀孕期间， 炎症性疾病往往会加重， 可能影响骨组织的代谢，包括骨、牙本质和 软骨 与骨组织变化相关的问题， 性腺功能缺失（如绝经后骨质减少） 认可. 拟议的实验将继续调查变化 在生殖过程中和没有卵巢的情况下， 功能 将在妊娠期和哺乳期研究以下目标， 大鼠：1）确定膳食钙对钙营养的影响， 激素（维生素D，甲状旁腺激素）和由此产生的变化， 钙代谢和骨组织（骨、软骨和牙本质）。 将使用生物化学和形态测量方法。 2)以确定是否 怀孕早期矿化组织的变化需要来自 胎盘 在这个实验中， 将被定性。 3)为了确定胎盘在 调节矿物质和骨骼代谢的变化. 怀孕中期 将特别强调界定下列机构的作用： 胎盘催乳素 4)定义生长调节素/胰岛素样蛋白的作用 妊娠期牙周组织中生长因子系统的变化。 为此 实验免疫反应性和生物活性生长调节素样物质将被 研究了 5)为了确定细胞增殖能力的变化， 牙周韧带在怀孕和哺乳期间。 的相对 未受刺激和机械刺激的成纤维细胞增殖 将确定刺激PDL。 6)为了确定 牙周组织在没有卵巢功能，以下 卵巢切除术 这些研究将提供有关女性生殖系统变化的重要新信息。 牙周组织（骨组织和软组织）在不同的生命周期 受生殖激素存在与否的影响。 这些 研究还将提供与炎症加重相关的信息， 口腔状况、内分泌骨质减少和绝经后 是的

There are changes in periodontal tissues during puberty, pregnancy and after menopause in human females. During pregnancy, for example, chronic inflammatory diseases are often aggravated and there are changes in mineral metabolism that might affect osseous tissues, including bone, dentin and cartilage. The problems associated with changes in osseous tissues in the absence of gonadal function (e.g. post-menopausal osteopenias) are well recognized. The proposed experiments will continue to investigate changes in periodontal tissues during reproduction and in the absence of ovarian function. The following objectives will be studied during pregnancy and lactation in rats: 1) To determine the effect of dietary calcium on calciotrophic hormones (vitamin D, parathyroid hormone) and the resultant changes in calcium metabolism and osseous tissues (bone, cartilage and dentin). Biochemical and morphometric approaches will be used. 2) To determine if changes in mineralized tissues in early pregnancy require factors from the placenta. For this experiment the changes that occur in pseudopregnancy will be characterized. 3) To determine the role of the placenta in mediation of the changes in mineral and skeletal metabolism at mid-pregnancy. Particular emphasis will be placed on defining the role of placental lactogens. 4) To define the role of the somatomedin/insulin-like growth factor system on periodontal tissues during pregnancy. For this experiment immunoreactive and bioactive somatomedin-like substances will be studied. 5) To determine the changes in the proliferative capacity of the periodontal ligament during pregnancy and lactation. The relative proliferation of fibroblasts in the unstimulated and mechanically stimulated PDL will be determined. 6) To determine the changes in periodontal tissues in the absence of ovarian function, following ovariectomy. These studies should yield important new information on changes in female periodontal tissues (osseous and soft tissues) during different life cycles influenced by the presence or absence of reproductive hormones. These studies will also provide information relevant to aggravated inflammatory states of the oral cavity, endocrine osteopenias, and post-menopausal osteoporoses.