BEHAVIORAL PHARMACOLOGY OF CHRONIC BENZODIAZEPINE USE

拟议中的实验将比较 耐受性发展中的行为制约因素 两种抗焦虑药物安定和咪达唑仑。容忍度 这些化合物的镇静作用是 镇静剂的滥用和临床应用。可广泛使用 咪达唑仑和安定被选作比较是因为 已知的诉讼持续时间的差异 牵涉到药物耐受和戒断两个过程。 给药的剂量将作为一项重要的 条件性因素和条件变量之间的关系 对咪唑安定的耐受性。我们将特别强调 条件性因素影响耐受性发展的过程 和戒断特征，而不是仅仅观察 条件性因素的存在。全面的描述 对这些抗焦虑药物的行为耐受性将会实现 通过评估应答率、应答期、 响应间隔时间，以及不同条件下的响应力 歌剧表演时间表。进一步划定 容忍度和退出过程在 重复使用这些药物将对 治疗滥用者和使用这些化合物治疗 鸦片、可卡因和酒精滥用。

The proposed experiments will compare the importance of behavioral conditioning factors in the development of tolerance to two anxiolytic drugs, diazepam and midazolam. Tolerance to the sedative effects of these compounds is an integral factor in the abuse and clinical use of sedatives. Widely available midazolam and diazepam have been selected for comparison because of the known difference in duration of action which has been implicated in both processes of drug tolerance and withdrawal. Dose of drug administered will be examined as an important variable in the relationship between conditioning factors and tolerance to midazolam. Special emphasis will be placed on the process of how conditioning factors affect tolerance development and withdrawal characteristics rather than merely observing the existence of conditioning factors. A comprehensive description of behavioral tolerance to these anxiolytics will be accomplished by evaluating response rates, duration of responses, interresponse times, and the force of the responses under various schedules of operant performance. Further delineation of tolerance and withdrawal processes which are important in the repetitive use of these drugs will have implications for the treatment of abusers and in the use of these compounds to treat opiate, cocaine and alcohol abuse.