A STUDY OF STIMULANT-INDUCED CONDITIONED DRUG EFFECTS

使用兴奋剂的一个重要方面是药物的作用 会对吸毒情况习以为常，所以即使是 在禁欲期间，暴露在这样的情况下可能 引发类药物反应，并引发渴望。为了努力 对药物有更基本的了解 条件化过程将使用动物模型，这将 允许详细描述行为和 调节药物条件作用的神经化学机制。这个 利用病变诱导的大脑半球多巴胺的动物制剂 不对称。当这种不对称的啮齿动物被给予 他们统一展示的多巴胺激动剂兴奋剂药物 旋转行为。在传统的动物行为模型中， 特异性药物诱导的反应通常是特殊的。这个 模型中药物诱导的行为反应的一致性 在本提案中使用允许在条件中的关键元素 将在各处理组之间指定流程，即 无条件的反应。通过这种增强的控制 条件变量，这一提议将(A)决定 吸毒史与条件反射强度的关系 药物反应，(B)探索可减弱 条件性反应，(C)检查条件性相互作用 药物之间的关系和(D)具体说明 无条件和条件性药物反应。

An important facet of stimulant drug use is that the drug effects can become conditioned to drug taking situations so that even during periods of abstinence exposure to such situations can trigger drug like reactions and provoked craving. In an effort to develop a more fundamental understanding of the drug conditioning process an animal model will be used which will permit a detailed characterization of the behavioral and neurochemical mechanisms which mediate drug conditioning. The animal preparation utilizes a lesion induced hemispheric dopamine asymmetry. When rodents with this asymmetry are given dopamine agonist stimulant drugs they uniformly exhibit rotational behavior. In conventional animal behavior models the specific drug induced response is frequently idiosyncratic. The consistency of the drug induced behavioral responses in the model used in this proposal permits a critical element in the conditioning process to be specified across treatment groups, namely, the unconditioned response. With this enhanced control over conditioning variables, this proposal will (a) determine the relationship of drug history to the intensity of the conditioned drug response, (b) explore methodologies which may attenuate the conditioned response, (c) examine conditioning interactions between drugs and (d) specify neurochemical correlates of the unconditioned and conditioned drug response.