PERIODONTAL TISSUE CHANGES DURING PREGNANCY-LACTATION

口腔慢性炎症性疾病往往加重。 在怀孕期间。此外，骨骼也有明显的变化 妊娠和哺乳期间的代谢，但牙齿的状况 矿化组织还不是很清楚。有可能发生的变化 妊娠和哺乳期可能出现的牙科软硬组织 可能会使一些人倾向于一些更严重的方面 牙周病。孕期牙槽骨改建和牙槽骨改建 哺乳时间将会确定。荧光骨标记物可在 间期和重塑活动由组织形态计量学确定 方法：研究方法。显微放射照片的定量图像分析将确定 骨骼结构和质量的变化。牙龈的存在和范围 炎症和/或水肿将在光和电子上被量化 显微镜水平。母体软硬组织在多大程度上 在幼崽断奶后恢复到正常状态将在 类似的方式。骨骼钙可以用来为胎儿补充钙 孕期骨骼矿化与孕期产奶量 哺乳。骨骼钙动员的程度可能取决于 膳食中钙的可利用性。的关系和重要性 妊娠期间饮食钙对牙槽骨改建和骨量的影响 将确定哺乳和断奶后的恢复情况。此外， 牙体整体钙代谢与牙体矿化变化的关系 将建立生殖周期中的组织重塑。这个 需要测量的一般钙代谢参数包括饮食摄入量、 肠道吸收能力、粪便和尿液排泄、胎盘和 乳腺转移和全骨钙。这些研究将 确定过程中牙体软硬组织的变化 妊娠、哺乳和断奶后恢复。饮食的重要性 钙摄入量对生殖系统矿化组织重塑的影响 还将建立周期。

Chronic inflammatory diseases of the oral cavity are often aggravated during pregnancy. In addition, there are marked changes in skeletal metabolism during pregnancy and lactation, yet the status of dental mineralized tissues is not well known. It is possible that changes in dental soft and hard tissues that may occur during pregnancy and lactation may predispose some individuals to some of the more serious aspects of periodontal disease. Alveolar bone remodeling during pregnancy and lactation will be determined. Fluorescent bone markers are given at intervals and the remodeling activity is determined by histomorphometric methods. Quantitative image analysis of microradiographs will determine changes in bone structure and mass. The presence and extent of gingival inflammation and/or edema will be quantified at the light and electron microscope levels. The extent to which the maternal hard and soft tissues are restored to 'normal' after weaning of the pups will be evaluated in a similar manner. Skeletal calcium may be used to supply calcium for fetal skeletal mineralization during pregnancy and milk production during lactation. The extent of skeletal calcium mobilization may depend on the availability of dietary calcium. The relationship and importance of dietary caclium to alveolar bone remodeling and bone mass during pregnancy, lactation and recovery after weaning will be determined. In addition, the relationship of overall calcium metabolism to changes in dental mineralized tissue remodeling during the reproductive cycle will be established. The general calcium metabolic parameters to be measured include dietary intake, intestinal absorption capacity, fecal and urinary excretion, placenta and mammary gland transfer and whole bone calcium. These studies will determine the changes that occur in dental soft and hard tissues during pregnancy, lactation and recovery after weaning. The importance of dietary calcium intake on mineralized tissue remodeling during the reproductive cycle will also be established.