PHARMACOLOGICAL MODULATION OF COCAINE EFFECTS

该项目将研究人类可卡因使用者之间的相互作用 可卡因与目前正在使用或建议用于 可卡因滥用的治疗。此外，该项目还将审查 可卡因对美沙酮维持患者的影响 可卡因滥用的高危人群。该项目旨在 确定潜在的益处(例如，在阻止 可卡因效应)和潜在危害(例如 心血管功能或可卡因引起的欣快感增加) 自服可卡因时产生的影响 用药理药剂治疗。在一个居住的人类中 实验实验室的生理学、主观性和 可卡因单独激发和联合激发对行为的影响 有了试验药物，将在受控下进行深入研究 双盲条件。在第一项研究中，可卡因的影响 在美沙酮依赖的可卡因滥用者中单独进行比较 以及使用非阿片类药物的可卡因滥用者。研究以考察 反复服用两种抗抑郁药的效果， 地塞帕明和曲唑酮，对可卡因挑战的回应将 然后在美沙酮维持患者中进行滥用 可卡因。第二组研究将考察这种相互作用 可卡因和建议用于可卡因滥用的药物之间 治疗(氟哌啶醇、溴隐亭、金刚烷胺和1-多巴) 非阿片依赖型可卡因滥用者。这些实验将 提供有关安全性和有效性的多方面数据 高危人群中的各种药理药物 对可卡因的自我管理，并可提供关于 以此作为治疗可卡因滥用者的决定依据。

This project will examine in human cocaine users the interactions of cocaine with drugs currently used or proposed for use in the treatment of cocaine abuse. In addition, the project will examine the effects of cocaine in methadone maintenance patients, a population at high risk for cocaine abuse. The project aims to identify potentially beneficial (e.g., efficacy in blockade of cocaine effects) and potentially harmful (e.g., changes in cardiovascular function or increases in cocaine-induced euphoria) effects produced when cocaine is self-administered during treatment with pharmacological agents. In a residential human experimental laboratory the physiological, subjective, and behavioral effects of cocaine challenge alone and in combination with a test drug will be intensively studied under controlled double-blind conditions. In the first study the effects of cocaine alone will be compared in methadone-dependent cocaine abusers and in non-opioid using cocaine abusers. Studies to examine the effect of repeated administration of two antidepressants, desipramine and trazodone, on response to cocaine challenge will then be conducted in methadone maintenance patients who abuse cocaine. A second group of studies will examine the interaction between cocaine and drugs proposed for use in cocaine abuse treatment (haloperidol, bromocriptine, amantadine, and 1-dopa) in non-opioid dependent cocaine abusers. These experiments will provide multifaceted data concerning the safety and efficacy of various pharmacological agents in a population at high risk for self-administration of cocaine and may provide information on which to base decisions about the treatment of cocaine abusers.