PERIODONTAL TISSUE CHANGES DURING PREGNANCY-LACTATION

牙周组织在青春期、妊娠期和 在人类女性绝经后。例如，在怀孕期间，慢性 炎症性疾病往往加重，矿物质也会发生变化。 可能影响骨组织的代谢，包括骨、牙本质和 软骨。与骨组织变化相关的问题 性腺功能缺失(如绝经后骨质疏松症)很好 被认可了。拟议中的实验将继续调查变化 在生殖过程中的牙周组织中以及在没有卵巢的情况下 功能。 以下目标将在怀孕和哺乳期间进行研究 大鼠：1)测定膳食钙对大鼠钙营养的影响 激素(维生素D、甲状旁腺激素)和由此引起的 钙代谢和骨组织(骨、软骨和牙本质)。 将使用生化和形态计量学方法。2)确定是否 妊娠早期矿化组织的变化需要来自 胎盘。在这个实验中，假孕发生的变化 将被描述为。3)确定胎盘在 调节人体矿物质和骨骼代谢的变化 怀孕中期。本课程将特别强调界定 胎盘催乳素。4)确定生长抑素/胰岛素样蛋白的作用 孕期牙周组织生长因子系统的研究为了这个 实验中免疫活性和生物活性生长抑素类物质将 学习。5)测定细胞增殖能力的变化。 妊娠和哺乳期间的牙周膜。相对的 非刺激性机械刺激对成纤维细胞增殖的影响 将确定受刺激的PDL。6)确定以下方面的变化 卵巢功能缺失时的牙周组织 卵巢切除术。 这些研究应该会为女性的变化提供重要的新信息 不同生命周期的牙周组织(骨和软组织) 受生殖荷尔蒙的存在或缺失的影响。这些 研究还将提供与严重炎症相关的信息 口腔状况、内分泌性骨量减少和绝经后 骨质疏松症。

There are changes in periodontal tissues during puberty, pregnancy and after menopause in human females. During pregnancy, for example, chronic inflammatory diseases are often aggravated and there are changes in mineral metabolism that might affect osseous tissues, including bone, dentin and cartilage. The problems associated with changes in osseous tissues in the absence of gonadal function (e.g. post-menopausal osteopenias) are well recognized. The proposed experiments will continue to investigate changes in periodontal tissues during reproduction and in the absence of ovarian function. The following objectives will be studied during pregnancy and lactation in rats: 1) To determine the effect of dietary calcium on calciotrophic hormones (vitamin D, parathyroid hormone) and the resultant changes in calcium metabolism and osseous tissues (bone, cartilage and dentin). Biochemical and morphometric approaches will be used. 2) To determine if changes in mineralized tissues in early pregnancy require factors from the placenta. For this experiment the changes that occur in pseudopregnancy will be characterized. 3) To determine the role of the placenta in mediation of the changes in mineral and skeletal metabolism at mid-pregnancy. Particular emphasis will be placed on defining the role of placental lactogens. 4) To define the role of the somatomedin/insulin-like growth factor system on periodontal tissues during pregnancy. For this experiment immunoreactive and bioactive somatomedin-like substances will be studied. 5) To determine the changes in the proliferative capacity of the periodontal ligament during pregnancy and lactation. The relative proliferation of fibroblasts in the unstimulated and mechanically stimulated PDL will be determined. 6) To determine the changes in periodontal tissues in the absence of ovarian function, following ovariectomy. These studies should yield important new information on changes in female periodontal tissues (osseous and soft tissues) during different life cycles influenced by the presence or absence of reproductive hormones. These studies will also provide information relevant to aggravated inflammatory states of the oral cavity, endocrine osteopenias, and post-menopausal osteoporoses.