INTEGRATED ROLE OF CCK ON THE GASTROINTESTINAL TRACT

虽然胆囊收缩素（CCK）是一种有效的胃肠道激素， 了解它的生理和病理。 随着近期 开发用于测量禁食的灵敏和特异性测定方法 和餐后血浆CCK水平，CCK的主要刺激物 CCK在靶组织中的分泌和生理作用可以 现在就下定决心。 这项研究将研究 神经递质和激素对CCK分泌的调节 以及CCK对靶组织的作用。 CCK分泌将是 与CCK对胃排空、胆囊收缩的作用有关 正常人和患者的膀胱收缩和胰岛素释放 各种疾病。 刺激CCK分泌的头， 胃和肠道的机制将进行研究和调节 CCK释放的神经激素药物将进行评估。 在 肥胖，CCK对胃排空改变的贡献， 胆囊收缩、胆结石形成和葡萄糖 还将研究代谢。 是否CCK分泌和 胆囊结石患者胆囊收缩正常 疾病将被调查。 由于CCK增强胰岛素 CCK对胰岛素分泌和血糖的作用 将在正常受试者和患有 非胰岛素依赖型糖尿病。 在大鼠模型中，CCK的饮食和药物调节 分泌和CCK合成的研究。 的影响 胆碱能、肾上腺素能和多巴胺能因子以及那些 蛙皮素、生长抑素和PYY对CCK的影响 释放将被确定。 胆囊收缩素的分泌与 肠CCK生物合成将通过测量 血浆CCK、小肠CCK含量和CCK mRNA水平。 这些在人类和大鼠中的研究应该提供对 CCK在健康和疾病中的作用

Although cholecystokinin (CCK) is a potent GI hormone, little is know about its physiology and pathology. With the recent development of sensitive and specific assays for measuring fasting and postprandial plasma levels of CCK, the major stimuli for CCK secretion and the physiologic role of CCK in target tissues can now be determined. This proposed research will study the regulation of CCK secretion by neurotransmitters and hormones and the action of CCK on target tissues. CCK secretion will be correlated with the actions of CCK on gastric emptying, gall bladder contraction, and insulin release in normals and patients with various diseases. Stimulation of CCK secretion by cephalic, gastric, and intestinal mechanisms will be studied and regulation of CCK release by neurohormonal agents will be evaluated. In obesity, the contribution of CCK to altered gasteric emptying, gall bladder contraction, gallstone development, and glucose metabolism will also be studied. Whether CCK secretion and gallbladder contraction are normal in patients with gallstone disease will be investigated. Since CCK potentiates insulin secretion, the role of CCK on insulin secretion and glucose tolerance will be evaluated in normal subjects and in patients with non-insulin dependent diabetes mellitus. In rat models, the dietary and pharmacologic regulation of CCK secretion and CCK synthesis will be studied. The effects of cholinergic, adrenergic, and dopaminergic factors as well as those of the gut hormones bombesin, somatostatin and PYY on CCK release will be determined. The relationship of CCK secretion to intestinal CCK biosynthesis will be evaluated by measuring plasma CCK, intestinal CCK content and CCK mRNA levels. These studies in humans and rats should provide insight into the role of CCK in health and diseases.