COLITIS AND COLON CANCER IN COTTON-TOP TAMARINS

这是对特发性溃疡性结肠炎研究的一个建议， 自发性大肠癌是一种很有前途的新动物模型。 这种动物是棉顶绢毛猴（Saguinus oedipus）， 最近被发现患有 结肠癌与慢性非感染性结肠炎相关。 是 除了人类之外，唯一已知的溃疡性结肠炎是 与癌症的高发病率有关。 调查工作将 以俄亥俄州州立大学的棉顶绢毛猴群为中心， 美国有三四个这种动物的聚居地。 这些绢毛猴将作为实验对照， 野生绢毛猴的研究 这项工作的紧迫性与这些动物有关 世界濒危物种的数量和 灭绝的最有可能的模式提供线索， 了解两种重要的人类疾病。 该提案针对 主要目的是确定棉尖病的病因 绢毛猴 该项目将确定是否自发性结肠炎和癌症 发生在生活在丛林栖息地的绢毛猴身上， 囚禁的表现。 在动物身上进行的初步实地研究， 不明的囚禁条件可能是诱发因素。 的 方法包括结肠的内窥镜检查和活组织检查， 不会以任何方式伤害动物 野生绢毛猴将被捕获， 检查并释放，毫发无伤，回到它们的原生栖息地。 具体 该项目的目标是：（1）记录发展和进展 结肠炎和癌症在俄亥俄州国家殖民地;（2）确定发病率 和结肠炎和癌症的严重程度在野生绢毛猴;（3）确定， 圈养是诱发因素是结肠炎的发展和 癌症后遗症;（4）确定寒冷的环境温度是否是压力 （5）确定压力的体液指标是否 在圈养动物中相对于野生动物的比例更高。

This is a proposal for studies on idiopathic ulcerative colitis and spontaneous large intestinal carcinoma in a promising new animal model. The animal is the cotton-top tamarin (Saguinus oedipus), which is a small South American monkey that has been discovered recently to suffer from colon cancer in association with chronic, non-infectious colitis. It is the only known animal, besides humans, in which ulcerative colitis is associated with a high incidence of cancer. The investigative work would center on The Ohio State University colony of cotton-top tamarin which is one of the three or four colonies of these animals in the Unites States. These tamarins will be experimental controls in parallel comparative studies on wild tamarins. Urgency of the work is related to these animals being on the world lid\st of endangered species and the danger of extinction of the most likely model for providing the clues to understanding of two significant human diseases. This proposal is directed to the major aim of identifying the etiologic factors involved cotton-top tamarin. The project will determine if spontaneous colitis and cancer occur in tamarins living in their jungle habitat or if the diseases are manifestations of captivity. Preliminary field studies in animals and that unidentified conditions in captivity might be precipitating factors. The methods will involve endoscopic examination and biopsy of the colon and will not harm the animals in any way. Wild tamarins will be captured, examined and released, unharmed, back into their native habitat. Specific aims of the project are to: (1) Document the development and progression of colitis and cancer in the Ohio State colony; (2) Determine the incidence and severity of colitis and cancer in feral tamarins; (3) Determine if captivity is the precipitating factor is development of colitis and the cancer sequel; (4) Determine if cold environmental temperatures are stress factors in captivity; (5) Determine if humoral indicators of stress are elevated in captive relative to feral animals.