COLITIS AND COLON CANCER IN COTTON-TOP TAMARINS

这是一项关于特发性溃疡性结肠炎和 自发性结肠癌是一种很有前途的新动物模型。 这种动物是棉顶锦蛇(Saguinus Oedipus)，它是一种小型 最近被发现患有这种疾病的南美猴子 结肠癌与慢性非感染性结肠炎相关。它是 除人类外，唯一已知的溃疡性结肠炎动物 与癌症的高发病率有关。调查工作将会 位于俄亥俄州立大学棉顶塔玛琳殖民地的中心 这种动物在美国的三或四个群体中的一个。 这些罗望子素将作为平行对照的实验对照。 野生罗望子的研究。这项工作的紧迫性与这些动物有关 登上濒危物种的世界之冠 最有可能提供线索的模型的消亡 对人类两种重大疾病的理解。这项建议是针对 以确定棉条发病因素为主要目的 塔玛琳。该项目将确定自发性结肠炎和癌症 发生在生活在丛林栖息地的罗望鱼身上，或者如果疾病是 囚禁的表现。在动物身上进行的初步实地研究 圈养中的不明条件可能是诱发因素。这个 方法将包括内窥镜检查和结肠活组织检查以及 不会以任何方式伤害动物。野生罗望鱼将被捕获， 经过检查并被释放，安然无恙地回到了它们的原生栖息地。特定的 该项目的目标是：(1)记录发展和进展 俄亥俄州立大学殖民地的结肠炎和癌症；(2)确定发病率 以及野生罗望子中结肠炎和癌症的严重程度；(3)确定 圈养是结肠炎发生和发展的诱因 癌症后遗症；(4)确定寒冷环境温度是否为应激 囚禁因素；(5)确定应激的体液指标是否 相对于野生动物在圈养环境中提升的。

This is a proposal for studies on idiopathic ulcerative colitis and spontaneous large intestinal carcinoma in a promising new animal model. The animal is the cotton-top tamarin (Saguinus oedipus), which is a small South American monkey that has been discovered recently to suffer from colon cancer in association with chronic, non-infectious colitis. It is the only known animal, besides humans, in which ulcerative colitis is associated with a high incidence of cancer. The investigative work would center on The Ohio State University colony of cotton-top tamarin which is one of the three or four colonies of these animals in the Unites States. These tamarins will be experimental controls in parallel comparative studies on wild tamarins. Urgency of the work is related to these animals being on the world lid\st of endangered species and the danger of extinction of the most likely model for providing the clues to understanding of two significant human diseases. This proposal is directed to the major aim of identifying the etiologic factors involved cotton-top tamarin. The project will determine if spontaneous colitis and cancer occur in tamarins living in their jungle habitat or if the diseases are manifestations of captivity. Preliminary field studies in animals and that unidentified conditions in captivity might be precipitating factors. The methods will involve endoscopic examination and biopsy of the colon and will not harm the animals in any way. Wild tamarins will be captured, examined and released, unharmed, back into their native habitat. Specific aims of the project are to: (1) Document the development and progression of colitis and cancer in the Ohio State colony; (2) Determine the incidence and severity of colitis and cancer in feral tamarins; (3) Determine if captivity is the precipitating factor is development of colitis and the cancer sequel; (4) Determine if cold environmental temperatures are stress factors in captivity; (5) Determine if humoral indicators of stress are elevated in captive relative to feral animals.