ELECTRORETINOGRAPHIC STUDIES IN DIABETIC RETINOPATHY

糖尿病患者视网膜电图异常 视网膜病变将被确定并与视网膜病变的严重程度相关 以及其他视觉功能变化（色觉和视野）。 ERG 要测量的参数是暗适应的b波振幅， 对符合Naka-Rushton理论的强度序列的响应 方程[（用于计算R max（最大响应）、K（半饱和 常数），n（响应函数的斜率）]和ERG振荡 电位（振幅和隐式时间）。 的能力 视网膜电图和其他视觉功能测试，以确定眼睛的风险 进展到更严重的视网膜病变阶段将在一个 对250名糖尿病患者进行了5-9年的纵向研究， 糖尿病视网膜病变的早期治疗 EGR参数，单独和 结合法恩斯托-孟塞尔100色调测试分数和戈德曼 基线时的视野评分将与随后的 增殖性糖尿病视网膜病变的发展。 如果这些测试证明 具有预测价值，它们可以在未来用于选择患者 具有高风险特征，以便更早或更多地进行 积极的内科或外科治疗干预。

The electroretinographic (ERG) abnormalities associated with diabetic retinopathy will be determined and related to the severity of retinopathy and to other visual function changes (color vision and visual fields). ERG parameters to be measured are the dark adapted b-wave amplitudes in response to an intensity series fit to the theoretical Naka-Rushton equation [(to compute R max (maximum response), K (half-saturation constant), n (slope of response function)], and the ERG oscillatory potentials (amplitude and implicit times). The ability of the electroretinogram and other visual function tests to identify eyes at risk to progress to the more severe retinopathy stages will be tested in a longitudinal 5-9 year study of 250 diabetic patients who are part of the Early Treatment Diabetic Retinopathy Study. The EGR parameters, alone and in conjunction with the Farnsworth-Munsell 100 hue test scores and Goldmann visual field scores at baseline will be related to the subsequent development of proliferative diabetic retinopathy. If these tests prove to have predictive value, they can be used in the future to select patients with high risk characteristics in order to institute earlier or more vigorous medical or surgical therapeutic intervention.