ORGANIZATION OF INFEROTEMPORAL CORTEX

拟议研究的长期目标是了解 颞下皮质区的功能组织， 决定了它们在视觉感知和记忆中的作用。 几行 有证据表明，下颞叶皮层（IT）是功能和 虽然是异源的，但关于这个问题，几乎没有一致的意见。 精确的数量、位置、组织和连接 目前的建议将集中在初始阶段， 颞叶的视觉处理，通过检查组织， 后颞下皮层（PIT）。 第一个目标是 以确定后部IT的位置和地形组织。 PIT及邻近病变视觉地形图的电生理标测 皮质区将用于确定后部IT是否包括 一个视觉区域，PIT（或TEO），两个区域，（PITd和PlTv），或一些 其他配置。 这些研究还将确定 PIT与相邻的纹前和颞下皮质区。 的 第二个目标是确定连接PIT与 视觉皮层的其他分支。 多发性逆行和顺行 将示踪剂注入PITd中的生理学特征位点 和/或PITv，皮质内标记将与 大脑半球间连接和皮质结构的模式。 这些数据将确定特定的视觉区域，也许模块 在向PITd提供上行和/或横向输入的区域内 和/或PITv。 此外，这些数据将确定 区域PITd和PITv与非地形组织的连接 IT和邻近皮质区的部分。 第三个目标是 确定PIT中是否存在模块化组织形式 这反映了来自不同处理流的隔离输入， 纹前皮质 多个顺行和可区分的逆行 示踪剂将被注射到V4、V4 t和V4 t区域的相应位点中 FST以确定来自区域V4中的不同隔室的输入， 或者来自区域V4 t和FST的输入，在PITd中彼此分离 和/或PITv。 这些研究将为流动提供新的思路 将视觉信息的信息输入颞叶， 深入了解高级模式的解剖学基础 辨别力和视觉记忆。

The long term goal of the proposed research is to understand the functional organization of inferotemporal cortical areas and to determine their role in visual perception and memory. Several lines of evidence indicate that inferotemporal cortex (IT) is functionally and antomically heterogeneous, yet there is little agreement concerning the exact number, location, organization and connections of well defined areas within IT. The current proposal will focus on the initial stages of temporal lobe visual processing by examining the organization, and connections of posterior inferotemporal cortex (PIT). The first goal is to determine the location and topographic organization of posterior IT. Electrophysiological mapping of visual topography in PIT and adjacent cortical areas will be used to determine whether posterior IT consists of one visual area, PIT (or TEO), two areas, (PITd and PlTv), or some other configuration. These studies will also determine the borders of PIT with adjacent prestriate and inferotemporal cortical areas. The second goal is to determine the patterns of connections linking PIT with other subdivisions of visual cortex. Multiple retrogade and anterograde tracers will be injected into physiologically characterized loci in PITd and/or PITv and the intracortical labeling will be correlated with the pattern of interhemispheric connections and cortical architecture. These data will identify the specific visual areas and perhaps modules within areas which provide ascending and/or lateral inputs to PITd and/or PITv. In addition, these data will identify the forward connections of areas PITd and PITv to non-topographically organized portions of IT and adjacent cortical areas. The third goal is to determine whether there is a form of modular organization within PIT that reflects segregated inputs from distinct processing streams in prestriate cortex. Multiple anterograde and distinguishable retrograde tracers will be injected into corresponding loci in areas V4, V4t, and FST to determine whether inputs from different compartments in area V4, or inputs from areas V4t and FST, are segegated from one another in PITd and/or PITv. These studies should provide new ideas concerning the flow of visual information into the temporal lobe and will provide new insights into the anatomical substrates of high level pattern discrimination and visual memory.