CONTACT LENS EFFECTS ON CORNEAL PH AND CORNEAL FUNCTION

长期佩戴隐形眼镜可能会导致几个 角膜的生理和形态变化。 标准 生理耐受性的基准一直是确定 通过测量角膜厚度进行角膜水合，假设 如果角膜厚度没有变化， 生理安全透镜。 不幸的是，许多具有高 氧透过率（Dk/L）几乎不引起角膜改变， 但几个月后可能会引起某些形态学变化 延长磨损。这表明角膜厚度测量 没有足够的灵敏度来检测微小但显著的变化， 角膜生理学或其他生理学改变正在发生 这可能并不总是伴随着角膜水合作用的变化。 最近，我们已经证明，接触透镜磨损可导致减少 有足够的生物学证据表明， 细胞外pH值的变化可以解释观察到的形态学 伴随接触透镜配戴的变化。如果隐形眼镜引起的 基质pH值的降低是这些形态学变化的原因， 研究基质pH值对角膜上皮细胞增殖的影响， 完整 在这项研究中，我们建议调查基质的范围， 伴随接触透镜配戴的pH变化，然后确定 透镜Dk/L、角膜厚度与眼内晶状体上皮细胞增生的关系 隐形眼镜引起的角膜病变 通过这些研究，我们希望 更全面地了解角膜变化的潜在病因 由接触透镜磨损引起。确定Lend Dk/L可以代表什么 长期配戴的生理安全透镜，并评估 使用pH测量作为监测和预测的临床方法 伴随接触透镜配戴的角膜变化，并作为评价 角膜健康

Contact lenses prescribed for extended wear can lead to several physiological and morphological changes in the cornea. The standard benchmark of physiological tolerance has been to determine changes in corneal hydration by measuring corneal thickness, the presumption being that the absence of changes in corneal thickness would provide a physiological safe lens. Unfortunately, many of the lenses having high oxygen transmissibility (Dk/L) cause little, if any, change in corneal thickness but may induce certain morphological changes after several months of extended wear. This suggests that either corneal thickness measurements are not sufficiently sensitive to detect small but significant changes in corneal physiology or that other physiological alterations are occurring that may not always be accompanied by a change in corneal hydration. Recently, we have demonstrated that contact lens wear can cause a decrease in stromal pH. There is sufficient biological evidence to indicate that a change in extracellular pH could account for the observed morphological changes accompanying contact lens wear. If the contact-lens-induced decrease in stromal pH is responsible for these morphological changes, then it is important to investigate the effects of stromal pH on corneal integrity. In this study we propose to investigate the range of stromal pH changes accompanying contact lens wear, and then determine the relationship between lens Dk/L, corneal thickness, and development of contact-lens-induced kerotopathies. From these studies, we hope to understand more completely the underlying etiology of corneal changes induced by contact lens wear. determine what lend Dk/L may represent a physiologically safe lens for extended wear, and assess the possibility of using pH measurements as a clinical method for monitoring and predicting corneal changes accompanying contact lens wear and as a test for evaluating corneal health.