Development of a penside diagnostic test for Fasciola hepatica

肝片吸虫是一种常见的肝吸虫，是世界上许多主要牲畜饲养地区羊和牛死亡、发病和生产损失的主要原因。在英国的高流行地区，由于缺乏具有成本效益的诊断测试，对动物群体进行地毯式治疗，这给寄生虫种群带来了产生耐药性的选择压力。对肝吸虫有效药物的耐药性越来越普遍。在BBSRC的资助下，我们与所有五个英国肉类和牛奶征税委员会合作，基于横向流动技术开发了一种初步的猪栏侧诊断测试原型。该项目的目的是生产一种有效的猪栏侧肝吸虫横向流动测试方法，该方法使用从牛或羊耳中采集的一滴血，农民可以自己使用，并准备由一家公司进行商业开发和生产。

Fasciola hepatica, the common liver fluke, is a leading cause of mortality, morbidity and production losses in sheep and cattle in many of the major livestock rearing areas of the world. In highly endemic regions of the UK, because of the lack of cost effective diagnostic tests, groups of animals are blanket treated, which puts selection pressure on parasite populations to develop resistance. Resistance to drugs effective against liver fluke is becoming widespread. With funding from BBSRC, in partnership with all five UK meat and milk levy boards, we developed a preliminary prototype pen-side diagnostic test for F. hepatica, based on lateral flow technology. The aim of this project is to produce a validated pen-side lateral flow test for liver fluke, which works with a drop of blood collected from the ear of a cow or a sheep that farmers can use themselves, and that is ready to be taken up by a company for commercial development and production.