ORGANIZATION OF INFEROTEMPORAL CORTEX

拟议研究的长期目标是了解 颞下皮质区域的功能组织和TO 确定它们在视觉感知和记忆中的作用。几行 有证据表明，颞下皮质(IT)在功能和功能上 自相矛盾的异质性，然而关于 准确的数量、位置、组织和联系 IT领域。目前的提案将侧重于初期阶段 通过检查组织来研究颞叶视觉处理，以及 后颞下皮质(PIT)的联系。第一个目标是 以确定后部IT的位置和地形组织。 坑区及邻近区域视觉地形图的电生理测绘 将使用皮质区域来确定后部IT是否包括 一个视觉区域，PIT(或TEO)，两个区域，(PITD和PLTV)，或一些 其他配置。这些研究还将确定 纹前皮质区和颞下皮质区相邻的凹陷。这个 第二个目标是确定连接坑道和 视皮层的其他分支。多重逆行和顺行 示踪剂将被注射到PITD的生理特征基因座 和/或PITv和皮质内标记将与 大脑半球间连接和皮质结构的模式。 这些数据将识别特定的可视区域，或许还包括模块 在向PITD提供上升和/或横向输入的区域内 和/或PITV。此外，这些数据将识别转发 PITd和PITv地区与非地形组织的连接 IT的部分区域和邻近的皮质区域。第三个目标是 确定PIT内部是否存在模块化组织形式 中来自不同处理流的隔离输入。 纹前皮质。多发性顺行和明显逆行 示踪剂将被注射到V4、V4t和 FST以确定来自区域V4中不同隔室的输入是否， 或者来自区域V4t和Fst的输入在PITd中彼此分割 和/或PITV。这些研究应该提供关于流动的新想法。 将视觉信息输入到颞叶，将提供新的 对高级模式的解剖学基础的洞察 辨别能力和视觉记忆。

The long term goal of the proposed research is to understand the functional organization of inferotemporal cortical areas and to determine their role in visual perception and memory. Several lines of evidence indicate that inferotemporal cortex (IT) is functionally and antomically heterogeneous, yet there is little agreement concerning the exact number, location, organization and connections of well defined areas within IT. The current proposal will focus on the initial stages of temporal lobe visual processing by examining the organization, and connections of posterior inferotemporal cortex (PIT). The first goal is to determine the location and topographic organization of posterior IT. Electrophysiological mapping of visual topography in PIT and adjacent cortical areas will be used to determine whether posterior IT consists of one visual area, PIT (or TEO), two areas, (PITd and PlTv), or some other configuration. These studies will also determine the borders of PIT with adjacent prestriate and inferotemporal cortical areas. The second goal is to determine the patterns of connections linking PIT with other subdivisions of visual cortex. Multiple retrogade and anterograde tracers will be injected into physiologically characterized loci in PITd and/or PITv and the intracortical labeling will be correlated with the pattern of interhemispheric connections and cortical architecture. These data will identify the specific visual areas and perhaps modules within areas which provide ascending and/or lateral inputs to PITd and/or PITv. In addition, these data will identify the forward connections of areas PITd and PITv to non-topographically organized portions of IT and adjacent cortical areas. The third goal is to determine whether there is a form of modular organization within PIT that reflects segregated inputs from distinct processing streams in prestriate cortex. Multiple anterograde and distinguishable retrograde tracers will be injected into corresponding loci in areas V4, V4t, and FST to determine whether inputs from different compartments in area V4, or inputs from areas V4t and FST, are segegated from one another in PITd and/or PITv. These studies should provide new ideas concerning the flow of visual information into the temporal lobe and will provide new insights into the anatomical substrates of high level pattern discrimination and visual memory.