GENETIC CONTROL OF MAMMALIAN DIFFERENTIATION

这项研究项目涉及哺乳动物的问题。 发育遗传学。它特别关注的是 确定特定的基因，包括结构基因和调控基因， 它们控制着胚胎发育和细胞的各个方面 在形态发生和生化水平上的分化。 影响发育和分化的小鼠突变 在这些研究中充当工具。关于遗传鉴定的问题 导致的特定发育缺陷提供了潜在的 阐明相应的正常发育机制 以及他们的基因控制。特别关注的是 小鼠白化病致死性缺失的复合体。这些似乎都是 包括与控制有关的调控基因 肝细胞分化。遗传学、发育学方法 生物学、生物化学、体细胞遗传学、电子显微镜、 细胞学和分子生物学为这些研究服务。这项研究 为出生研究提供了模型系统 人类新陈代谢的缺陷和先天错误。它打开了 关于先天畸形病因的新认识和新观点 强调了相似条件下的遗传异质性 症状，例如糖原储存疾病和其他代谢疾病 异常现象。

This research project deals with problems of mammalian developmental genetics. In particular it is concerned with the identification of specific genes, both structural and regulatory, which control various aspects of embryonic development and cell differentiation on levels of morphogenesis and biochemistry. Mutations in the mouse affecting development and differentiation serve as tools in these studies. The identification of genetically caused specific developmental defects provides the potential of elucidating the corresponding normal mechanisms of development and their genetic control. Particular attention centers on a complex of lethal albino deletion in the mouse. These appear to include regulatory genes concerned specifically with the control of liver cell differentiation. Methods of genetics, developmental biology, biochemistry, somatic cell genetics, electronmicroscopy, cytology and molecular biology serve these studies. The research proposed here provides model systems for the study of birth defects and inborn errors of metabolism in humans. It opens up new views on the etiology of congenital malformations and underscores the genetic heterogeneity of conditions with similar appearances, e.g. glycogen storage diseases and other metabolic abnormalities.