Establishing a network to catalyse collaboration for reducing immune ageing (CARINA: CAtalyst Reducing ImmuNe Ageing)

在整个生命过程中保持良好的健康受到一系列不同因素的影响，重要的是我们了解所有这些因素，以便能够采取措施预防老年健康状况不佳。我们的免疫系统在健康的许多方面起着至关重要的作用。大多数人知道，我们的免疫系统保护我们免受传染病的侵袭，当它发生故障时，可能会导致自身免疫性疾病。然而，免疫系统的行为可以产生更广泛的后果，它与许多不同的疾病有关，如心血管疾病、痴呆症、糖尿病、肾脏疾病和癌症。间接影响也会发生，例如，炎症会限制关节的运动，从而导致活动量减少和相应的健康损失。因此，了解如何在整个生命过程中保持健康的免疫系统对健康的老年至关重要。免疫系统本身有多个不同的组成部分，这意味着研究的专业性通常会导致个别研究人员孤立地研究免疫衰老的一个方面。此外，免疫系统本身也受到其他系统的影响，对免疫的充分理解需要考虑其他影响的影响，如营养、新陈代谢、运动、时间生物学、神经生物学、微生物区系。了解与健康有关的行为的社会驱动因素对于传播有关具有长期有益后果的干预措施的信息也是至关重要的。因此，至关重要的是，我们必须建立研究人员协作团队，以促进老年人免疫健康的改善。为了使这项活动长期持续下去，我们必须鼓励和支持早期职业学者在这一领域发挥带头作用。拟议的Carina网络将积极与来自不同学科和不同职业阶段的研究人员接触，以促进他们专注于免疫衰老的研究。第一次会议将展示一些已经表示有兴趣的个人的简短活动总结(2张幻灯片，每张5分钟)。不同小组的分组会议将设定任务，讨论如何实现我们的每个目标，这些目标是：对关键研究问题进行差距分析，建立新的跨学科合作伙伴关系，吸收新技术和实验系统，探索具有免疫力的学科交叉调查干预途径，以增强免疫力广泛的利益相关者参与每个小组将总结他们的讨论，我们将确定将整理并发送给整个网络的关键观察结果。这确定了综合专门知识潜在的初始关键领域，并可能产生研究影响。随后，将建立信息和数据共享平台。我们将举行一系列在线会议，扩大我们的讨论范围，以进一步确定将研究活动集中到影响衰老免疫的新方向的领域，并确定该网络的任何进一步的个人/机构/行业成员。我们将鼓励我们职业生涯初期的学者来领导讨论。在头12个月内举行的第二次面对面会议将混合讨论小组，并围绕有希望的研究领域安排讨论--理想情况下，这些差距可以通过跨学科研究来填补。12-24个月将遵循类似的会议模式，不同之处在于我们将能够确定网络合作伙伴提供跨学科赠款的领域。英国免疫学会(BSI)的转包支持对于有效的沟通和会议交付至关重要，而且比招聘单一项目经理更具成本效益，因为BSI的许多不同经验丰富的人员可以为网络的不同方面提供支持。

Maintaining good health across the lifecourse is influenced by a large range of different factors, and it is important that we understand all these factors to be able to take steps to prevent ill health in older age. Our immune system plays a crucial role in many aspects of health. Most people understand our immune system protects us from infectious disease, and when it malfunctions it can cause autoimmune disease. However, the actions of the immune system can have much wider consequences and it has been implicated in many different diseases such as cardiovascular disease, dementia, diabetes, kidney disease and cancer. Indirect effects occur also, for example inflammation can restrict movement in the joints, which leads to reduction in activity and consequential loss of fitness. Therefore, understanding how to maintain a healthy Immune System throughout the lifecourse is essential to a healthy older age.There are multiple different components of the immune system itself, which means that specialism in research usually results in individual researchers studying just one aspect of immune ageing in isolation. Moreover, the immune system is itself affected by other systems and a full understanding of immunity needs to consider the effect of other influences such as nutrition, metabolism, exercise, chronobiology, neurobiology, microbiota. Understanding social drivers of health-related behaviour is also critical to communicating information about interventions that have long term beneficial consequences. Therefore, it is critical that we build collaborative teams of researchers to facilitate improved immune health in older age. To sustain the activity through to the long term it is essential that we encourage and support early career academics to take a lead in this area. The proposed CARINA network will actively engage with researchers from different disciplines, and at different career stages, to facilitate focussing their research towards immune ageing. An initial meeting will showcase a short summary of activities from a number of individuals who have already expressed an interest (2 slides, 5 mins each). Breakout sessions of different groups will be set tasks to discuss how to deliver each of our aims, which are: A gap analysis of key research questions Establish new interdisciplinary partnerships Assimilate new technology and experimental systems Explore disciplinary cross-over with immunityInvestigate routes for intervention to enhance immunityWiden stakeholder engagement Each group will summarize their discussions and we will identify key observations that will be collated and sent to the whole network. This identifies initial key areas of potential for integrated expertise and would potentially deliver research impact. Subsequently, platforms for information and data sharing will be established. There will be a series of online meetings where we will expand our discussions to further pinpoint areas that coalesce research activity towards a new direction for impact on ageing immunity and identify any further individual/institutional/industrial members of the network. Our early career academics will be encouraged to lead the discussions. A second face to face meeting, within the first 12 months, will intermix the discussion groups and structure the discussions around the promising areas for research - gaps that can ideally be met through interdisciplinary studies. Months 12-24 will follow a similar pattern of meetings, the difference being that we will be able to identify areas for interdisciplinary grants by the partners of the network. Subcontracted support from the British Society for Immunology (BSI) is crucial for effective communication and conference delivery and is more cost effective than recruiting a single Project Manager, as many different experienced individuals from the BSI can deliver support for different aspects of the network.