SYNTHETIC RECEPTORS AND FUNCTIONAL GROUP ARRAYS

许多新的和相当独特的有机分子将被制备出来 和评价 这项工作的目标是定义一些 编写合成材料所需的原则和一般准则 可以控制有机化学反应的微环境。 这些方法依赖于合成方法和程序， 本实验专门用于准备有组织的功能组 阵列和凹分子。 两个新系统测试催化剂 预组织功能组阵列的潜力。 另一系统 旨在评估应力、应变或 基质反应性的畸变。 在该项目的另一部分，额外的结合位点将 附着在成功的水溶性宿主上， 选择这些主机。 在以下情况下，需要结合的特异性 微环境是选择性地结合反应性中间体 或反应的过渡态。 一种新的分子系统， 与自身和反式十氢化萘的结合有待进一步开发。 良好的烷烃结合位点可能导致有用的选择性方法。 烷烃官能化

A number of new and quite unique organic molecules will be prepared and evaluated. The goal of this work is to define some of the principles and general guidelines necessary to prepare synthetic microenvironments which may control organic chemical reactions. The approaches rely on synthetic methods and procedures created in this lab specifically for preparing organized functional group arrays and concave molecules. Two new systems test the catalytic potential of pre-organized functional group arrays. Another system is designed to evaluate the effects of stress, strain, or distortion on substrate reactivity. In another part of the project, additional binding sites will be attached to successful water soluble hosts in order to enhance the selectivity of these hosts. Specificity of binding is required if a microenvironment is to selectively bind a reactive intermediate or transition state of a reaction. A new molecular system which binds to itself and to trans-decalin is to be further developed. Good alkane binding sites may lead to useful methods of selective alkane functionalization.