CHIRAL SYNTHETIC RECEPTORS FOR ORGANIC MOLECULES

本项目的目标是拓宽理论和经验 为理解水介质中受体-底物相互作用奠定基础。 最重要的生物过程（免疫反应，酶催化， 细胞转运、核酸复制）涉及非共价结合 有机分子之间的联系 这一现象将在 复杂的模型系统。 为了实现这一点，人工合成的一般策略 将开发受体。 合成被设计成简短的， 有效，因此可以容易地对受体结构进行改变 结构对受体-底物相互作用的影响可以是 彻底评估。 特定分子对缔合常数的定量测量 合成受体和底物将通过分光光度法测定。 测量. 测定的缔合常数和预测的缔合常数的比较 将得到相互作用的自由能。 以这种方式可用 用于定量受体-底物相互作用的计算方法可以 要优雅。 在此过程中获得的知识的潜在技术应用 项目是令人兴奋和多样化的。

The objective of this project is to broaden the theoretical and empirical bases for understanding receptor-substrate interactions in aqueous media. Most important biological processes (immune response, enzymic catalysis, cell transport, nucleic acid replication) involve non-covalent binding between organic molecules. This phenomenon is to be investigated in sophisticated model systems. To accomplish this, general strategies for the synthesis of artificial receptors will be developed. The syntheses are designed to be short and efficient, so that variations on the receptor structure may be easily made and the effect of structure on the receptor-substrate interactions can be thoroughly evaluated. Quantitative measurements of association constants for specific pairs of synthetic receptors and substrates will be determined by spectrophotometric measurement. Comparisons of measured association constants and predicted free energies of interaction will be made. In this way available computational methods for quantifying receptor-substrate interactions can be refined. The potential technological applications of the knowledge gained in this project are exciting and diverse.