SYNTHETIC RECEPTORS AND FUNCTIONAL GROUP ARRAYS

将制备一些新的和相当独特的有机分子。 并进行了评估。这项工作的目标是定义一些 制备合成材料所需的原则和一般指南 可能控制有机化学反应的微环境。 这些方法依赖于在 本实验专门为准备有组织的功能小组 阵列和凹形分子。两个新系统测试了催化剂 预先组织的官能团阵列的潜力。另一个系统 旨在评估应力、应变或 对底物反应性的扭曲。 在该项目的另一部分中，额外的结合位点将是 附着在成功的水溶性宿主上，以增强 这些宿主的选择性。在以下情况下，需要绑定的专一性 微环境是选择性地结合活性中间体 或反应的过渡态。一种新的分子体系 与其自身结合和反式十氢菲结合是有待进一步开发的。 良好的烷烃结合部位可能导致有用的方法来选择 烷基官能化。

A number of new and quite unique organic molecules will be prepared and evaluated. The goal of this work is to define some of the principles and general guidelines necessary to prepare synthetic microenvironments which may control organic chemical reactions. The approaches rely on synthetic methods and procedures created in this lab specifically for preparing organized functional group arrays and concave molecules. Two new systems test the catalytic potential of pre-organized functional group arrays. Another system is designed to evaluate the effects of stress, strain, or distortion on substrate reactivity. In another part of the project, additional binding sites will be attached to successful water soluble hosts in order to enhance the selectivity of these hosts. Specificity of binding is required if a microenvironment is to selectively bind a reactive intermediate or transition state of a reaction. A new molecular system which binds to itself and to trans-decalin is to be further developed. Good alkane binding sites may lead to useful methods of selective alkane functionalization.