ENDOCRINE FUNCTION AND STRUCTURE OF RELAXIN

本研究的最终目的是阐明其内分泌功能。 松弛和确定激素的哪些结构特征是 对靶细胞的反应是必不可少的。调查将包括 松弛素的生物合成及其分泌机制的研究进展 转移到目标单元格。已经设计了一些实验来阐明 松弛素-受体相互作用模式与原代细胞的性质 对松弛素刺激的反应。这项工作的另一个方面将受到关注 根据耻骨联合的大分子重塑机制， 松弛素的主要靶器官。最后，我们将尝试确定 松弛素是通过不同的因子来调节其反应，还是松弛 它本身就是一个依赖生长激素发挥作用的因素。 对金鱼鲨松弛蛋白的结构研究将包括 继续。

The ultimate objective of this study is to elucidate the endocrine function of relaxin and to determine which of the structural features of the hormone is essential for the response in the target cells. The investigation will include the study of the mechanism of biosynthesis of relaxin, its secretion and transfer to the target cells. Experiments have been designed to elucidate the mode of relaxin-receptor interaction and the nature of the primary cellular response to relaxin stimulation. Another aspect of this work will be concerned with the mechanism of the macromolecular remodelling of the symphysis pubis, the major target organ of relaxin. Finally an attempt will be made to determine whether relaxin mediates its response via a different factor or whether relaxin itself is a factor dependent upon growth hormone for its action. Structural studies of the shark relaxin from Odontaspis tauris will be continued.