ORGANOMANGANESE COMPLEXES IN ORGANIC SYNTHESIS

芳烃锰三羰基络合物提供了一种很好的方法 在极其温和的条件下合成二芳基醚。我们有 探索了该技术在制备二芳基醚中的应用 具有氨基酸侧链，作为瑞斯托菌素合成的模型，以及 偶联反应的进行不会损失分子的旋光性 受保护的氨基酸。建议制定一份详细的 含卤代芳烃-Mn(CO)_3络合物的合成研究 官能化取代基及取代卤化物的研究 取代苯氧化物和其他亲核试剂的范围。一些简单的 但重要的天然产物，如异马豆酚、胡萝卜素和 将被合成以说明这一方法的用处 技术。最终，锰络合物将可用来 可应用于新型三芳基二醚和二芳基的合成 糖肽类抗菌药物中发现的乙醚氨基酸亚基 瑞斯托菌素。完全合成瑞斯托菌素是一项艰巨的任务， 但作为一个长期目标是极其重要的，因为这些化合物 是潜在的有价值的广谱抗生素，对 葡萄球菌感染的治疗时，其他抗生素 效果不佳。 三烯-锰(CO)_3和三烯-锰(CO)_3形成碳-碳键的新方法 将研究二烯基锰(CO)3络合物，以期其 作为有机合成中间体的最终应用。特例 将注意使用羰基锰来实现 聚喹烷衍生物的形成。

Arene manganese tricarbonyl complexes provide an excellent means of synthesizing diaryl ethers under extremely mild conditions. We have explored the application of this technique for preparing diaryl ethers having amino acid side chains, as a model for ristocetin synthesis, and the coupling reaction proceeds without loss of optical activity of the protected amino acid. It is proposed to set in hand a detailed investigation into the synthesis of haloarene-Mn(CO)3 complexes containing funcitonalized substituents and to study the displacement of halide by a range of substituted phenoxides and other nucleophiles. A number of simple but important natural products, such as isomagnolol, cularines, and neothalibrine, will be synthesized to illustrate the usefulness of this technique. Ultimately, manganese complexes will be made available which can be applied to the construction of the novel triaryldiether and diaryl ether amino acid subunits found in the glycopeptide anitibiotics related to ristocetin. A total synthesis of ristocetin is a formidable undertaking, but as a long term objective is extremely important, since these compounds are potentially valuable broad spectrum antibiotics which are useful in the treatment of staphylococcal infections when other antibiotics are ineffective. New methods for carbon-carbon bond formation using triene-Mn(CO)3 and dienyl-Mn(CO)3 complexes will be investigated, with a view to their ultimate application as organic synthesis intermediates. Particular attention will be paid to the use of manganese carbonyl to effect the formation of polyquinane derivatives.