NMR-BASE: Nuclear Magnetic Resonance for Biomolecule Analysis in Supported Environments

在发明新的生物医学和生物材料方面，最大的挑战是了解它们在分子水平上如何在它们设计工作的背景下发挥作用。虽然孤立地考察这些材料是可能的，也是必要的，但它们的真正目的是在它们真实的生活背景或对它们的模拟中揭示出来的。为了弥合在设计药物如何发挥作用的层面上存在的差距，将建立基于核磁共振的设施，以帮助用户“看到”他们的分子在复杂基质中的行为，这些基质在治疗目的方面具有重要意义。将为英国科学界建立核磁共振基础，为研究人员提供最先进的设备，以检查分子结构和行为的精细细节，从而帮助分子设计过程取得进展。该设备将适用于最广泛的样本类型，并将能够支持活细胞，以及提供对组织、凝胶和其他构成许多生物材料和系统基础的“软”材料的研究。该设备将使各种科学方法能够用于研究分子的真实情况，并将有利于新药和生物材料的设计过程。它将为广泛的英国用户群提供新的培训机会，包括当地和全国的博士生，为他们的研究提供独特的设备，以及支持他们的工作人员。这些设备将安置在斯特拉斯克莱德大学的核磁共振设施内，这是一所世界领先的技术大学，拥有以最佳方式托管和运行核磁共振数据库所需的技能和专业知识。

The biggest challenge in the invention of new biomedicines and biomaterials is understanding how they function at a molecular level in the context for which they are designed to work. While it is possible and necessary to examine such materials in isolation, their true purpose is revealed in their real living contexts or mimics of these. To bridge the gap that exists at the level of how designed medicines work, the NMR-BASE facility will be established to help users "see" the behaviour of their molecules in complex matrices, those that are significant in the context of therapeutic purpose. NMR-BASE will be established for the UK scientific community by providing researchers with access to state-of-the-art equipment to examine the fine details of molecular structure and behaviour in ways which will help the molecule design process to progress. The equipment will be suitable for the widest range of sample types and will be capable of supporting live cells as well as providing access to the study of tissues, gels and other "soft" materials that form the basis of many biological materials and systems. The equipment will enable a variety of scientific approaches to be used for studying molecules in their true contexts and will benefit the design process for new medicines and biomaterials. It will provide new training opportunities for a wide UK user base including PhD students both locally and nationally, providing access to unique equipment for their research along with the staff to support them. The equipment will be housed within the NMR Facility at the University of Strathclyde, a world-leading technological university which has the skills and expertise required to host and run NMR-BASE optimally.