Acid and Base Organocatalysts

酸和碱有机催化剂

• 批准号: 2247279
• 负责人: Steven Kass
• 金额: $ 19.2万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2247279&HistoricalAwards=false
• 关键词: Acid; Base; Organocatalysts

With the support of the Chemical Catalysis Program in the Division of Chemistry, Professor Steven Kass of the Department of Chemistry at the University of Minnesota is studying a new strategy for improving catalysts. The goal of this research is to create practical, useful, and environmentally friendly catalytic systems. To facilitate these ends, the Kass team is taking advantage of the attraction between opposite charges, e.g., electrostatic interactions. This project spans a broad range of chemical disciplines from catalysis to synthesis and the outcomes will affect the chemical, pharmaceutical, and materials industries. Consequently, it is well suited for training and educating young scientists who will go on to careers in these science and technology fields. An NSF-Research Experiences for Undergraduates grant enhances the broader impact of this work.A goal of this award is to prepare and fully characterize charge-enhanced acids and bases, a largely underdeveloped research area. These studies are to include the examination of the catalytic abilities of these acids and bases in a range of chemical transformations. As part of this, we will also study structural variants of the catalysts as a means of increasing reactivity and selectivity. Critical to achieving our goals is that physical studies be carried out to identify key reactive intermediates to elucidate mechanism. With these goals and methods in mind, we are studying the ability of charge-enhanced catalysts to control enantioselectivity and enable the synthesis of chiral compounds. More explicitly, this award will help us to develop charge-activated metallocene complexes. In addition to charge, these catalysts will also contain additional Brønsted acid/hydrogen bond donors and enable multifunctional cooperativity to be studied and exploited. The impact of chiral additives and solvents on the resulting enantioselectivities will also be examined.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学催化项目的支持下，明尼苏达大学化学系的Steven Kass教授正在研究一种改进催化剂的新策略。本研究的目标是创造实用、有用、环保的催化系统。为了实现这些目标，卡斯团队正在利用相反电荷之间的吸引力，例如静电相互作用。该项目涵盖了从催化到合成的广泛化学学科，其成果将影响化学、制药和材料工业。因此，它非常适合培训和教育将在这些科学和技术领域从事职业的年轻科学家。nsf本科生研究经验资助增强了这项工作的广泛影响。该奖项的目标是制备和充分表征电荷增强酸和碱，这是一个很大程度上欠发达的研究领域。这些研究将包括检查这些酸和碱在一系列化学转化中的催化能力。作为其中的一部分，我们还将研究催化剂的结构变体，作为提高反应性和选择性的手段。实现我们的目标的关键是进行物理研究，以确定关键的反应中间体来阐明机制。考虑到这些目标和方法，我们正在研究电荷增强催化剂控制对映体选择性和合成手性化合物的能力。更明确地说，这个奖项将帮助我们开发带电活化的茂金属配合物。除了电荷外，这些催化剂还含有额外的Brønsted酸/氢键供体，可以研究和开发多功能协同作用。手性添加剂和溶剂对所得到的对映体选择性的影响也将进行研究。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。