APPLICATIONS OF INTRAMOLECULAR ALLYLSILANE CYCLIZATIONS

本提案重点介绍了烯丙基硅烷环合反应的应用。 形成中等大小的环。新的和昂贵的合成 会议和新欧莱曼利用了这一独特的优势 环扎法。此外，新的方法论已经被 建议进一步发展这一环扎术。这个 具有几个迈克尔受体的底物的环化反应，或 内部亲核分子，是我们早期的强大延伸 学习。几项针对环状骨架的初步研究 赤霉酸，赤霉酸，方酮，麦角菌素A，紫杉醇， 树突碱和一叶珊瑚碱已被提出以扩展 我们的环形成工艺的范围。 烯丙基硅烷碳环化的区域仍然很大程度上 尚未开发，具有巨大的潜力。追求的是 这里提出的实验将进一步证明 这种环扎方法的能力。

This proposal focuses on the application of allylsilane cyclizations to form medium-sized rings. Novel and expendient syntheses of confertin and neolemnane exploit advantages unique to this annulation strategy. In addition, new methodology has been proposed to further develop this annulation procedure. The cyclization of substrates possessing several Michael acceptors, or internal nucleophiles, is a powerful extension of our earlier studies. Several pilot studies directed toward the ring skeletons of gascardic acid, gibberellic acid, quadrone, ophiobolin A, taxol, dendrobine, and securinine have been presented to expand the scope of our ring-forming processes. The area of allylsilane carbocyclizations remains largely unexplored and has significant potential. Pursuit of the experiments proposed here will further demonstrate the capabilities of this annulation methodology.