CYCLOADDITION REACTIONS USING ORGANOMETALLICS

在本研究中，两个新的五个- 将研究成员碳环的成环反应。在……里面 其中的一个反应，以及α，β-不饱和丙烯 络合物与烯丙基锡酮结合形成5- 成员环。在另一个反应中，环丙基卡宾- 铬络合物与乙炔结合生成β- 甲氧基环戊酮衍生物。我们将展示这是如何实现的 反应可用于合成具有药用价值的化合物 化合物，如三喹烷、前列腺素和三尖杉酯碱。 五元碳环体系是一种非常常见的 多种药用天然产物的结构特征 产品。五-环加成反应方法的研究进展 成员环将允许化学家开发出高度收敛的 这些非常有用的化合物的合成。因此， 提案中提出的研究将是一笔巨大的财富 有机化学和药物化学领域。

In this research, the scope and limitation of two novel five- membered carbocyclic ring-forming reactions will be studied. In one of these reactions, and alpha, beta-unsaturated acyliron complex is combined with an allylstannone to form a five- membered ring. In the other reaction, a cyclopropylcarbene- chromium complex combines with an alkyne to produce beta- methoxycyclopentenone derivatives. We will show how this reaction can be used to synthesize pharmaceutically-interesting compounds such as triquinanes, prostaglandins, and cephalotaxine. The five-membered carbocyclic ring system is a very common structural feature in many pharmaceutically-interesting natural products. Development of cycloaddition approaches to five- membered rings will allow chemists to develop highly convergent synthesis to these highly useful compounds. As a result, the research presented in the proposal will be a great asset to the fields of organic chemistry and medicinal chemistry.