Improved Liquid and Mixed Metal Activation for Organic Synthesis

目前的申请是对EP/G00272X/1（考虑于2008年6月初）的修订后立即重新提交，它的评级很高，但优先级小组可用的资金不足。推荐人对该应用程序中主要科学的评论非常强烈(例如：“我见过的最新颖、最令人耳目一新的提案”、“真正优秀的想法”、“杰出的”等等)，但资金环境不允许它获得支持。我们发现催化液态镓可以用于前所未有的高效金属活化，从而简化了有机金属化合物RM和金属氢化物的快速制备。该技术允许形成新的前所未有的空气稳定芳基烷烃；直接使用金属混合物进行改进/高效的RX和氢胺活化，得到al- hy化物[HAl(NR2)2]和[HAl(NR2)Cl]和DABCO稳定的空气稳定有机金属[(RnY3-n)2(DABCO)] （Y = I, NR2）。这些衍生试剂将用于快速通量（不对称）筛选1,2-添加到FG-RCHO和亚胺；不饱和酰基氰化物的1,4添加物；烯烃和炔氢铝化及其在相关工艺中的后续应用。

This present application represents a revised immediate resubmission of EP/G00272X/1 (considered early June 2008) it was highly rated but insufficient funds were available to the prioritisation panel. Referee comments on the lead science in this application were very strong (e.g. 'most novel and refreshing proposal I haves seen', 'truly excellent ideas', 'outstanding', etc.) but the funding environment did not allow its support.We have found that catalytic liquid gallium can be used for highly efficient unprecedented metal activation allowing simplified rapid preparation of organometallics RM and metal hydrides. The technique allows formation of new unprecedented air-stable aryl alanes; direct use metal-mixtures for improved/efficient RX and hydrogen and amine activation to provide Al-hydrides [HAl(NR2)2] and [HAl(NR2)Cl] and the DABCO stabilized air-stable organometallics [(RnY3-n)2(DABCO)] (Y = I, NR2). These derived reagents are to be used in fast throughput (asymmetric) screening of 1,2-additions to FG-RCHO and imines; 1,4-additions to unsaturated acylcyanides; alkene and alkyne hydroalumination and their subsequent use in related processes.