POLY (ORGANOPHOSPHAZENES) FOR BIOMEDICAL USES

这个节目的目的是探索一种新的类的可能性， 合成聚合物，聚（有机腈），可用于三个领域 生物医学的：（1）作为非血栓形成材料，用于替代 组织，特别是在并入循环系统的装置中;（2）作为 用于化疗药物受控、靶向递送的载体大分子 药物;和（3）作为酶，细胞，亲和性 组分或氧化还原物质。 最近的工作已经开辟了结合药物的合成路线， 类固醇、磺胺类药物或多巴胺转化为聚磷腈， 身体pH值对无害的小分子，同时释放活性药物 分子。 在接下来的工作中，我们希望扩大这条路线的范围， 更广泛的药物分子的受控释放。 还计划在 肝素和其他非血栓形成的附着方法的发展 物种到聚合物，可能在人工器官研究中有价值。 在 此外，酶，亲和底物和金属卟啉的连接， 将探索聚磷腈。

The purpose of this program is to explore the possibility that a new class of synthetic polymers, the poly(organophosphazenes), can be utilized in three areas of biomedicine: (1) as non-thrombogenic materials for the replacement of tissues, especially in devices incorporated into the circulatory system; (2) as carrier macromolecules for the controlled, targeted delivery of chemotherapeutic drugs; and (3) as immobilization substrates for enzymes, cells, affinity components, or redox species. The recent work has opened up synthetic routes to the binding of drugs such as steroids, sulfa drugs, or dopamine to polyphosphazenes that will decompose at body pH to harmless small molecules with concurrent release of the active drug molecules. In the forthcoming work we hope to expand the scope of this route for the controlled release of a wider range of drug molecules. Also planned is the development of methods for the attachment of heparin and other non-thrombogenic species to polymers that may be of value in artificial organ research. In addition, the linkage of enzymes, affinity substrates, and metalloporphyrins to polyphosphazenes will be explored.