MICROPUNCTURE STUDY OF KIDNEY FUNCTION

微穿刺术旨在阐明其生理和功能 几个领域的肾功能病理生理学将继续进行。特定的 项目包括识别和定义肾脏和个体的实验 肾单位机制在高血压发病初期的作用 5~8周龄自发性高血压大鼠血压迅速升高。 对照研究将在WKY动物身上进行。对老鼠的研究将继续进行 肾动脉阻断1小时后并发急性肾功能衰竭 主要是在随排便功能障碍的恢复中 并确定几种实验干预对ITS的影响 当然了。容量扩张大鼠急性单侧失神经可进一步 失神经肾的尿流量显著增加，伴随着 对侧神经支配的肾脏减少盐和水的排泄。 两者均发生在肾小球滤过率或肾血流量没有变化的情况下，并且是由相互作用引起的 肾小管重吸收速率的变化。将进行实验，以 确定在这种情况下，神经肾脏重吸收的增加 这种情况是由于去神经后神经活动增加所致。

Micropuncture studies directed at elucidation of the physiology and pathophysiology of kidney function in several areas will be continued. Specific projects include experiments to identify and define the renal and individual nephron mechanism involved in the initial phase of hypertension when arterial blood pressure rises rapidly in 5 to 8 week old spontaneously hypertensive rats. Control studies will be done in WKY animals. Studies will continue on rats with acute renal failure following 1 hour of renal artery occlusion directed primarily at following the disturbance in excretory function in the recovery phase and determining the effects of several experimental interventions on its course. Acute unilateral denervation in volume expanded rats produces a further marked increase in urine flow from the denervated kidney which is accompanied by a decrease in salt and water excretion by the contralateral innervated kidney. Both occur without change in GFR or renal blood flow and result from reciprocal changes in the rate of tubular reabsorption. Experiments will be performed to ascertain if the increased reabsorption in the innervated kidney under this condition results from increased neural activity subsequent to denervation.