Kruppel-like factors and the methylome

该项目旨在验证KLF/SP转录因子家族部分通过与DNA中甲基化的胞嘧啶核苷酸的动态相互作用发挥作用的假设。这是它们作为重新编程先锋因子的功能以及它们协调分化和器官发生的能力的基础。相反，甲基化状态的动态变化通过招募KLF/SP家族蛋白作为特定的效应器来结合或脱离基因组中的新的调控元件。这个项目将解决遗传学中的一种新范式，这可能会支持发展。

This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.