POLY ORGANOPHOSPHAZENES FOR BIOMEDICAL USES

我们打算继续努力开发聚磷腈聚合物， 用作人工组织的半渗透性水凝胶和膜 用于药物缓释的膜、基质和用于药物缓释的基质。 酶和其它生物活性剂的固定化。 工作 将围绕选择合适的亲水侧基 附着在高分子链上，发展高分子交联 反应，以及使用这些材料来介导小分子的扩散。 分子溶质。 还计划进行生物相容性研究， 通过合作研究安排进行。

We intend to continue our efforts to develop polyphosphazene polymers as hydrogels and membranes for use as artificial tissues, semipermeable membranes, matrices for the slow release of drugs, and substrates for the immobilization of enzymes and other biologically-active agents. The work will revolve around the selection of suitable hydrophilic side groups attached to the polymer chain, the development of polymer crosslinking reactions, and the use of these materials to mediate the diffusion of small molecule solutes. Biocompatibility studies are also planned, to be undertaken through a collaborative research arrangement.