PERINATAL DETERMINANTS OF DEVELOPMENT

该项目旨在描述持久和暂时的 生理和行为发育差异 一年中不同季节出生的动物， 年轻的动物如何决定一年中的季节和标准， 母亲在传达季节信息方面的特殊作用。 具体项目包括：1）确定前期和后期的作用; 出生后光周期对生理和行为发育的影响; 2)确定母体褪黑激素在HER发展中的作用 后代; 3）评估其他非褪黑激素因素的作用 受母亲光周期的影响，进而影响幼鼠 发育; 4）确定是否在光周期出生的幼崽 一年中不同季节的典型反应不同， 出生后标准光周期; 5）评估功能 出生的幼崽发育差异的意义 模拟一年中不同季节的繁殖者的母亲; 6） 确定早期毛皮生长的意义和持久性， 在冬季光照条件下饲养的母亲所生的幼崽。 拟议 工作可能会导致概念和干预措施， 深入了解出生季节如何改变 精神分裂症、酗酒和人类生长模式 人口

This project seeks to characterize the enduring and temporary physiological and behavioral developmental differences among animals born during different seasons of the year, with emphasis on how young animals determine the season of the year and the par- ticular role of the mother in communicating seasonal information. Specific projects include: 1) determining the role of Pre- and postnatal photoperiod on physiological and behavioral development; 2) determining the role of maternal melatonin on development of her offspring; 3) assessing the role of other, non-melatonin factors affected by photoperiod in the mother that in turn influence pup development; 4) determining whether pups born in photoperiods typical of various seasons of the year respond differently to a standard photoperiod postnatally; 5) assessing the functional significance of differences in pup development in litters born to mothers simulating breeders from various seasons of the year; 6) determining the significance and permanence of early fur growth in pups born to mothers housed in winter photoperiods. The proposed work may lead to concepts and interventions that could provide insight into how season of birth alters the incidence of schizophrenia, alcoholism and growth pattern in the human population.